Bioprocessing Application Notes & Case Studies
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Quantifying Heterogeneous AAV Capsid Loading Using Mass Photometry
3/28/2024
Quantifying the proportions of heterogeneously filled AAVs is a critical step in therapy characterization. This mass photometer is used to distinguish and measure heterogeneously filled AAVs.
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Scalable mRNA Affinity Capture
3/26/2024
The POROS Oligo dT(25) affinity resin offers a solution for the purification of mRNA by providing efficient purification, high binding capacity, and selectivity, while removing impurities.
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Monoclonal Antibody Aggregate Polish And Viral Clearance Using HIC
3/26/2024
Explore highly productive POROS HIC polishing processes in both bind–elute and flowthrough modes that outcompeted legacy clinical processes designed for two highly challenging case studies (MAbs A and B).
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AAV Process Intensification Using High Salt Lysis And Salt Tolerant Endonuclease
3/25/2024
In the production of adeno-associated virus (AAV) vectors, cell lysis involves challenges addressed through high salt concentrations and a salt-tolerant endonuclease, enhancing titer and infectivity.
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Find The Right T Cell Expansion And Phenotype Balance For Cell Therapy
3/22/2024
Explore this study that works to determine the optimal concentrations of IL-7 and IL-15 for T cell expansion, as well as how to produce the desired phenotype while requiring less protein.
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Touch-Free T Cell Expansion With A Fill-And-Forget Workflow
3/22/2024
Explore a bioreactor for large-scale, low-cost immune cell therapy manufacturing paired with a "fill-and-forget" workflow and discover how robust T cell expansion can be achieved.
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High Yield Protein Production System For Suspension CHO Cells
3/22/2024
Reduced the risk of contamination caused by repeated handling of the culture during transient protein production in suspension CHO cells
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Get Full Control Of Your T Cell Isolation
3/21/2024
This study demonstrates the automated magnetic isolation of CD4/CD8+ cells from fresh or frozen leukapheresis using a functionally closed cell processing system paired with a modular application.
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Scale Up Strategy For Oncolytic HSV-1 Vector Manufacturing
3/21/2024
Discover how a novel, large-scale production method for herpes simplex virus type-1 vectors has the potential to accelerate the progress of gene therapy and bring it closer to widespread application.
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Cell Line Development For High-Titer Lentivirus Vector Production
3/21/2024
Explore a groundbreaking method to significantly enhance LV vector yield using engineered HEK293T cells. This approach paves the way for more efficient and large-scale production of LV vectors.