INSIGHTS ON DOWNSTREAM MANUFACTURING
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Risk Control | Bulk Filling Application
Learn about a bulk filling system that enables you to achieve risk control, accuracy, and superior product recovery in your fill and finish operations.
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Bulk Filling Of Drug Substance | Accurate Aliquoting
Bulk filling drug substances in traditional facilities is often a lengthy, manual process where operators are relied upon to adjust pump controls to achieve accurate filling. This method, spanning multiple shifts, increases process risk through errors that can compromise accuracy.
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Streamlining Single-Use Assemblies In The Bulk-Fill Step Of Downstream Processing
Single-use (SU) systems and components are growing in demand as they offer minimal contamination risk. Review a standardized SU assembly for bulk-fill processing that aims to improve efficiency.
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New Instrumentation Expands Sediment Velocity AUC’s Utility
Purified adeno-associated viruses (AAVs) are prepared as a variety capsid species that must be characterized and quantified to ensure safety and efficacy.
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Identify And Quantify AAV Fill States Using Analytical Centrifugation4/24/2024
Purified AAVs are prepared as a variety capsid species. To ensure gene therapy safety and efficacy, it is crucial to characterize and quantify those species.
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De-Risking The Aseptic Drug-Filling Process And Optimizing Production4/17/2024
Aseptic drug-filling poses significant risks for manufacturers that can increase costs and timelines. Leveraging proven expertise and efficiency can ensure the production of safe, efficacious products.
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Robust Development Of Downstream Process Technologies For AAV4/17/2024
The focus of this study was to optimize the three primary downstream processing steps for AAV particle purification utilizing a design of experiments (DoE) methodology and screening devices.
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Tips For Viral Vector Production4/16/2024
Learn about how meticulous purification optimization can maximize recovery and impurity removal by leveraging scalable downstream technologies to meet regulatory and process economy requirements.
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What Is A Viral Vector?4/16/2024
Review a novel adenovirus production process that offers scalable, single-use equipment-compatible solutions, reducing production time and cross-contamination risks.
DOWNSTREAM MANUFACTURING SOLUTIONS
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SKU: 4486-13
Item Name: Bosch Capsule Filler, Model GKF1400
Category: Capsule Fillers/Encapsulators > Hard Gel Capsule Filler
Manufacturer: Bosch
Location: Cleveland, OH
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The SamuxMP Auto is the automated version of Refeyn’s solution for AAV characterization, autonomously measuring up to 24 samples in approximately 90 minutes. The instrument offers quick measurements of purity, aggregation and loading of AAV samples of any serotype – with high precision and reproducibility.
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Thermo Scientific™ POROS™ Caprylate Mixed-Mode Cation Exchange Chromatography Resin is designed to remove moderate to high levels of aggregates during downstream processing of therapeutic antibodies in flow-through mode. As a mixed-mode, weak cation-exchange resin, POROS Caprylate resin effectively removes other impurities, such as host-cell proteins and a wide range of high molecular weight species.
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- SKU: 4385-1
- Category: Centrifuges > Basket Type
- Manufacturer: Sartorius
- Location: United Kingdom
- Material of Construction: Stainless Steel
- Model/Type: KSEP 6000
- Serial Number: ATSK6000S022107
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Achieve high performance protein chromatography with scalable agarose-based ion exchange chromatography resins that are compatible with a wide range of temperature, pH, chemical and physical conditions.