Bioprocessing Application Notes & Case Studies
-
Predicting Human Liver Damage With A More Accurate In Vitro Hepatotoxicity Assay
4/9/2024
This study explores whether a species-specific, multicellular, in vitro hepatotoxicity assays utilizing Liver-Chips can provide a greater understanding of hepatotoxicity mechanisms than animal models.
-
Investigating Key Mechanisms Of Parkinson’s With A Novel Model
4/9/2024
Efforts to develop a dynamic “brain-on-a-chip” model that closely resembles the human substantia nigra could be applied to study mechanisms of Parkinson’s disease.
-
A Better Immune Response To Vaccination: Using Lymphoid Follicle Organ-Chips
4/9/2024
Discover a first-of-its-kind human LF-Chip containing B, T, plasma and antigen-presenting cells to test functional immunization responses to vaccines and adjuvants in vitro.
-
Creating An Effective Pre-Clinical Model Of Bone Marrow
4/9/2024
A Bone Marrow-Chip (BM-Chip) was created to recapitulate relevant hematopoietic cell types in a three-dimensional (3D), mechanically active next-generation in vitro model.
-
Revolutionizing Viral Infectious Disease Research And Drug Discovery
4/8/2024
Learn how Organ-Chips are being used to rapidly identify promising treatments, investigate virus evolution, and analyze how mechanical forces influence the innate immune response to viral infections.
-
Evaluating Cell Culture Medium Performance In CAR-T Processes
4/8/2024
This study examines the expansion, functionality, and phenotype of CAR-T cells cultured in the CellGenix® GMP T cell culture medium (TCM) compared to other commercially available T cell media.
-
Comparison To And Advantages Over Traditional Chemometrics Models
4/5/2024
As Raman spectroscopy, with partial least squares (PLS) models, becomes more popular in bioprocesses applications it's important to recognize the challenges this approach presents.
-
Real-Life Application Of Intensified Chromatography – See The Results
4/5/2024
Explore the impact and benefits of multi-column chromatography, taking into consideration product quality consistency as well as the potential cost and resin savings compared to batch chromatography.
-
Rev-Up AAV Genome Production In Upstream Manufacturing
3/28/2024
By increasing recombinant AAV titers, this AAV enhancer can help reduce upstream manufacturing costs and lower the cost per therapeutic dose.
-
Optimize And Monitor AAV Capsid Purification Using Mass Photometry
3/28/2024
Study the performance of a mass photometer that was used to analyze AAV samples at various stages of purification to confirm column binding, and to monitor elution from the chromatography column.