Insights On Downstream Manufacturing
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Understanding Viral Clearance During Anion-Exchange Chromatography
3/26/2024
A design of experiments (DoE) study examined the anion-exchange process in general and to draw possible correlations between such properties and overall viral clearance capability.
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Scalable mRNA Affinity Capture
3/26/2024
The POROS Oligo dT(25) affinity resin offers a solution for the purification of mRNA by providing efficient purification, high binding capacity, and selectivity, while removing impurities.
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Gain Confidence In Your ADCs With Stability Prediction Experiments
3/26/2024
Learn more about the importance of stability experiments early in the development process for antibody drug conjugates (ADCs) with the data collected being used to mitigate stability problems during extended storage or high-concentration use of the ADC.
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Monoclonal Antibody Aggregate Polish And Viral Clearance Using HIC
3/26/2024
Explore highly productive POROS HIC polishing processes in both bind–elute and flowthrough modes that outcompeted legacy clinical processes designed for two highly challenging case studies (MAbs A and B).
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Get Full Control Of Your T Cell Isolation
3/25/2024
This study demonstrates the automated magnetic isolation of CD4/CD8+ cells from fresh or frozen leukapheresis using a functionally closed cell processing system paired with a modular application.
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AAV Process Intensification Using High Salt Lysis And Salt Tolerant Endonuclease
3/25/2024
In the production of adeno-associated virus (AAV) vectors, cell lysis involves challenges addressed through high salt concentrations and a salt-tolerant endonuclease, enhancing titer and infectivity.
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The Increasing Demand For Sterile Filtration Of High Concentration Drugs
3/21/2024
Explore the current trends and challenges with manufacturing high-concentration drug products and an approach to performing extensive filterability trials without a high quantity of expensive product.
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What Is The DynaChromâ„¢ Single-Use Chromatography System?
3/21/2024
This chromatography system offers a flexible solution, paired with an advanced software platform, allowing easy integration with downstream process automation.
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GMP-Compliant Viral Vector Production Line
3/19/2024
The OBiO Intelli-M manufacturing site can accommodate comprehensive and diversified solutions for large-scale production, with eight virus production lines with the production capacity from 20 L to 2000 L.
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Gradient Performance Of The DynaChrom Single-Use Chromatography System
3/18/2024
Explore a single-use chromatography system that introduces micro-efficiencies into the manufacturing workflow process, potentially leading to time and cost savings throughout the production life cycle.