Explore this guide to using nano-differential scanning fluorimetry (nanoDSF) and how it can impact and improve your screening data quality

Techniques to measure biotherapeutics stability and how they support biologics development, formulation, and storage for successful approval of your mAb-based therapeutic on the market.

Learn about Dynamic Light Scattering (DLS), a powerful method to characterize the purity and aggregation state of your biologics, and how it helps improve your candidates’ selection process.

This article outlines the process of conducting thermal stability experiments and the significance of self-association parameters.

Explore the construction of ADCs (antibody-drug conjugates), as well as importance of stability and engineering considerations in the development process.

Thermal stability is one of the most common critical quality attributes of therapeutic proteins. Learn about 4 methods for thermal stability assessment of proteins.

Review what light scattering techniques tell you, how to set them up, and how they’re used for developability assessment.

Learn more about stability studies specifically and how to gain insight on multiple stability parameters on your biologics candidates all at once.

Biophysical characterization measurements from nanoDSF, DLS, backreflection, and SLS, are valuable to provide stability attributes of your biologics.

Developability profiles of biologics candidates help you avoid risk by collecting many quality attributes. Learn which attributes are evaluated during development and approaches for their measurement.

Explore questions about how to use Dynamic Light Scattering to design, select, and advance the most stable biologics candidates.

Learn how biologics scientists use DLS to get more detailed and reliable insights into their candidates so they de-risk downstream development.

Risk mitigation strategies are critical for transitioning a biologic therapeutic from the lab to the clinic. Learn how dynamic light scattering measurements predict self-interaction propensity of early stage biologics.

Learn why this protein science group found it important to build developability profiles from biophysical stability attributes of their candidates and how they did it.

To gain insight into your protein’s structure and function, understanding what affects its stability is key. Read this blog to learn about 6 parameters to monitor protein stability.

Learn how to apply information from Dynamic Light Scattering (DLS) measurements to support your decision-making process for several experiments of biologics development.

Read how Merck KGaA uses light scattering measurements to prioritize candidates and improve their outcomes.

Learn about the objectives for both IND and BLA filing processes for mAb therapeutics, and the importance of stability studies throughout the different phases of approval.

To determine colloidal stability of biologics candidates, scientists rely on particle size and dispersity in solution using DLS experiments. Learn how five formulation changes affect the DLS read-out.

Learn how you can perform a multi-parameter stability assessment that examines multiple aspects of antibody-drug conjugate (ADC) stability in parallel.

Learn the basics of how ADCs are engineered and why that makes them such powerful tools to target cancers with precision.

Learn more about the importance of stability experiments early in the development process for antibody drug conjugates (ADCs) with the data collected being used to mitigate stability problems during extended storage or high-concentration use of the ADC.

What is nanodifferential scanning fluorometry (nanoDSF), how is it used to assess the conformational stability of proteins, and what aspects of stability should be considered when assessing biologics?

This presentation provides a deep dive into the practical considerations of antibody-drug conjugates (ADCs) development and characterization.

Watch this 10 min walkthrough of the Prometheus Panta and experience first-hand how easy it is to start an experiment with the instrument.

Explore how the discovery group at Merck used Prometheus Panta to assess multiple developability characteristics of their mAb therapeutics and gained deeper insight into the quality attributes of their candidates.

Learn about Prometheus Panta experiment assay set-up, sample handling, and experimental design, and which stability experiments are possible.

Full developability profiles de-risk the selection process for biologics candidates during early development workflows.

A successful biologic candidate screening campaign depends on having the right tools. Learn what DLS data tells you about your biologics and how to use it for candidate selection.

Expert or novice, gain the benefits of reviewing how the autocorrelation function derived from Dynamic Light Scattering (DLS) is generated and how to assess DLS data quality.

Walk through the process of selecting an optimal buffer for a vaccine antigen and some steps you can follow to help make your own decision.

See how the Prometheus Panta instrument and 4 integrated technologies – nanoDSF, DLS, SLS and backreflection – provide high-quality sizing and stability information about your biologics’ developability.

Join Product Specialist Dr. Leah Pandiscia to learn about the physical phenomenon behind Dynamic Light Scattering (DLS), and how DLS provides deeper understanding of your protein’s behavior.