Dynamic Light Scattering Easily Explained: What It Tells You About Your Protein Therapeutic

Join Dr. Leah Pandiscia, Product Specialist at NanoTemper Technologies, to learn about the physical phenomenon that drives Dynamic Light Scattering (DLS), and see a few examples of how DLS gives you a deeper understanding of your protein’s behavior.

What is DLS?

Dynamic Light Scattering (DLS) is a powerful method used to determine the size of particles in a solution, and identify populations of differently-sized particles. When applied to protein samples, data derived from DLS provides information about the purity and aggregation state of your protein preps, and provides useful insight into the stability of your proteins.

Why is it important to protein scientists?

Changing the environment of a protein of interest — whether by reformulating its buffer, making mutations, or adding compounds or excipients — alters the size and stability of that protein.

To assess the impact of such changes, reliable, precise, and sample-friendly analytical methods – like DLS – are required. This way, with information about your protein's behavior, you make confident decisions and favor conditions that ensure protein stability throughout your workflow.