Bioprocessing Application Notes & Case Studies
-
Creating An Effective Pre-Clinical Model Of Bone Marrow
4/9/2024
A Bone Marrow-Chip (BM-Chip) was created to recapitulate relevant hematopoietic cell types in a three-dimensional (3D), mechanically active next-generation in vitro model.
-
Revolutionizing Viral Infectious Disease Research And Drug Discovery
4/8/2024
Learn how Organ-Chips are being used to rapidly identify promising treatments, investigate virus evolution, and analyze how mechanical forces influence the innate immune response to viral infections.
-
Evaluating Cell Culture Medium Performance In CAR-T Processes
4/8/2024
This study examines the expansion, functionality, and phenotype of CAR-T cells cultured in the CellGenix® GMP T cell culture medium (TCM) compared to other commercially available T cell media.
-
Comparison To And Advantages Over Traditional Chemometrics Models
4/5/2024
As Raman spectroscopy, with partial least squares (PLS) models, becomes more popular in bioprocesses applications it's important to recognize the challenges this approach presents.
-
Real-Life Application Of Intensified Chromatography – See The Results
4/5/2024
Explore the impact and benefits of multi-column chromatography, taking into consideration product quality consistency as well as the potential cost and resin savings compared to batch chromatography.
-
Rev-Up AAV Genome Production In Upstream Manufacturing
3/28/2024
By increasing recombinant AAV titers, this AAV enhancer can help reduce upstream manufacturing costs and lower the cost per therapeutic dose.
-
Optimize And Monitor AAV Capsid Purification Using Mass Photometry
3/28/2024
Study the performance of a mass photometer that was used to analyze AAV samples at various stages of purification to confirm column binding, and to monitor elution from the chromatography column.
-
Quantifying Heterogeneous AAV Capsid Loading Using Mass Photometry
3/28/2024
Quantifying the proportions of heterogeneously filled AAVs is a critical step in therapy characterization. This mass photometer is used to distinguish and measure heterogeneously filled AAVs.
-
Scalable mRNA Affinity Capture
3/26/2024
The POROS Oligo dT(25) affinity resin offers a solution for the purification of mRNA by providing efficient purification, high binding capacity, and selectivity, while removing impurities.
-
Monoclonal Antibody Aggregate Polish And Viral Clearance Using HIC
3/26/2024
Explore highly productive POROS HIC polishing processes in both bind–elute and flowthrough modes that outcompeted legacy clinical processes designed for two highly challenging case studies (MAbs A and B).