Bioprocessing Application Notes & Case Studies
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Bakuchiol Synthesis Optimization In S. Cerevisiae During Scale Up From 250mL To 5L
4/15/2024
Explore the significance of cost-effectiveness in synthetic biology and the successful scaling up of a process involving S. cerevisiae for the production of bakuchiol.
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Simplifying CHO Cell Line Genetic Stability Testing
4/11/2024
Here, we describe the use of whole genome sequencing to perform a comprehensive assessment of genetic stability in clonally derived CHO cell banks using the Aptegra™ CHO genetic stability assay.
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Scaling Up mAb Process Development To A 5L Bioreactor
4/10/2024
This study, conducted with cloud-connected bioreactors designed to accommodate CHO cells, showcases this technology transfer by comparing results obtained from shake flask cultures at various scales.
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Optimized Performance Model For Yield And Quality Of The mRNA Product
4/9/2024
Optimize your mRNA production by identifying an optimum set of conditions for the IVT reaction that produces high-quality mRNA in high yield using a design of experiment (DoE) approach.
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Evaluating On-Target/Off-Tumor Effects Of Cancer Immunotherapies
4/9/2024
A promising class of engineered T-cell engaging bispecific antibodies (TCBs) is revolutionizing cancer treatment, but safety concerns persist. Organs-on-Chips offer a human-relevant solution.
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Exploring Neuroinflammation, Neurodegeneration With A Brain Organ-Chip
4/9/2024
Examine how Organ-on-a-Chip technology, accurately mimicking human neuroinflammation, offers promising human-relevant avenues for neurodegenerative disease research and therapeutic development.
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Studying Gut Inflammation And Barrier Disruption With Organ-On-A-Chip Technology
4/9/2024
See how the Colon Intestine-Chip has been employed to model cytokine-mediated inflammation and barrier disruption in the intestine.
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Predicting Human Liver Damage With A More Accurate In Vitro Hepatotoxicity Assay
4/9/2024
This study explores whether a species-specific, multicellular, in vitro hepatotoxicity assays utilizing Liver-Chips can provide a greater understanding of hepatotoxicity mechanisms than animal models.
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Investigating Key Mechanisms Of Parkinson’s With A Novel Model
4/9/2024
Efforts to develop a dynamic “brain-on-a-chip” model that closely resembles the human substantia nigra could be applied to study mechanisms of Parkinson’s disease.
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A Better Immune Response To Vaccination: Using Lymphoid Follicle Organ-Chips
4/9/2024
Discover a first-of-its-kind human LF-Chip containing B, T, plasma and antigen-presenting cells to test functional immunization responses to vaccines and adjuvants in vitro.