Simple Western With Jess Uncovers Possible New Strategy To Prevent And Treat COVID-19

Jess Reveals A Link Between Elovanoids And ACE2 Expression

As the global death toll from the COVID-19 pandemic approaches 1 million, the scientific community has jumped into high gear to understand and treat SARS-CoV-2 infection. It is understood that SARS-CoV-2 entry into host cells involves the binding of the viral spike protein to the human ACE2 receptor.¹ Thus, ACE2 has become a target of extreme interest in studies to understand and prevent infection.

In a recent App Note, we described how Simple Western, the automated Western blot platform from ProteinSimple, can detect and quantify ACE2 and the associated protease TMPRSS2 in human cells. For this purpose, Simple Western offers many advantages, including automation, fast time to results, and reproducible quantification. In an exciting new preliminary study just released in Research Square, researchers at LSU and USC used ProteinSimple’s newest Simple Western platform, Jess™, to detect and quantify ACE2 in lung cells to study SARS-CoV-2 infection, and their findings were remarkable.²