04.05.24 -- Process Development With "The End In Mind" For Startups

By giving examples for the implementation of closed, connected processing in large-scale manufacturing, this paper will help you explore and assess options that work for your objectives.

Review a successful optimization process that increases the yield of plasmids, the precursors for mRNA synthesis, and achieves a scalable, efficient process for high-quality mRNA production.

Explore more detail on how to achieve a 2000L scale-up and studies that have been optimized through process characterization and experimental approaches to better understand key process steps.

Strategically optimize your upstream and downstream processes and decrease the timeline from optimization to commercial manufacturing.

Learn about high throughput biologic automation and GMP master cell banking services as well as variable selection services that search the SQL space to find promoters.

Expression of inclusion bodies has historically suffered a bad reputation in the industry. So, how do these two routes, soluble and insoluble, compare in terms of their advantages and challenges?

Learn about the significance of sensitivity in drug development and how researchers can improve their pipelines by employing more sensitive models.

Inclusion bodies, which are typically undesirable, are now gaining attention for their potential to produce a range of difficult-to-express proteins in E. coli systems.

Explore the benefits of using mRNA for vaccines and therapeutics, and learn how to address technical, intellectual property, and cost considerations when considering commercial production.

Explore a resin-based method showing promise for effectively reducing high aggregate levels in mAbs, delivering high monomer yields with low aggregate impurity levels, and enhancing mAb purification.

Maintaining a cleanroom facility that remains safe for your workers — and where the therapeutics they produce remain safe for patients — can ease your compliance concerns.

Here, we review the Technical Report (TR) outlining how particle counters are used to classify and monitor cleanroom performance, ensuring it meets required standards under normal operating conditions.

Here, we provide systematic methods to increase return on investment. Discover the seven primary investment recovery channels.

In this chapter of The Aqueous Cleaning Handbook, we explore the key definitions of aqueous cleaner ingredients, the types of aqueous cleaners, and the application of isoelectric points to cleaning.

The growing mRNA vaccine market — projected to reach $127.3 billion by 2027 — is fueling high demand for mRNA, which has resulted in a critical need to address mRNA manufacturing bottlenecks.