What are the challenges that come with the selection, development, and optimization of media for cell therapies? Cell therapy is a complex but promising alternative to traditional disease treatments, but its strict manufacturing guidelines limit its availability.
cGMP plasmid DNA is an essential starting material for viral vector production, but current manufacturing strategies are struggling to meet yield requirements, resulting in high cost of goods (COGS) and supply-chain bottlenecks. At-line and frequent spent media analysis can enable a faster in-house process development pace.
Producing diverse cell and gene therapeutics requires that various cells be used based on the specific application. This short webinar reviews at-line methods for cell culture media analysis, the importance of meticulously designing the culture medium to match requirements, and data from two case studies.
There is an urgent need for easy-to-implement continuous monitoring of nutrients and metabolites, enabling dynamic feedback control. Explore a platform that addresses the challenges of online nutrient and metabolite monitoring and control. Process development labs are no longer limited by manual sampling or overly complex analytical instruments.
To evaluate the consistency, linearity, and specificity of MAVERICK™ measurements in the complex media environment of bioreactor runs, known quantities of glucose and lactate were serially spiked into spent CHO medium and spent HEK293 medium samples. Explore the details of this plug-and-play, in-line, Raman-based PAT solution.
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