04.17.24 -- A Novel Approach To Managing Risks In Aseptic Processing Of Cell & Gene Therapies

Study the performance of a mass photometer that was used to analyze AAV samples at various stages of purification to confirm column binding, and to monitor elution from the chromatography column.

Learn more about an effective, biodegradable solution for the viral inactivation process that controls protein impurities and is compatible with downstream unit operations.

Learn about host cell proteins (HCPs) and the sensitive and specific orthogonal methods necessary to identify individual HCP impurities that persist through DS purification processes.

Learn about an adsorption isotherm class that is based on a colloidal description of proteins and achieves increased accuracy at high column loading in IEX modeling.

Analyze the throughput performance of sterilizing grade filters across moderate-to-high concentrations of mAbs and immunoglobulins and explore how filter selection can impact your process.

Find ways to achieve the flexibility you need to maximize the cost-effectiveness of Protein A resins and employ varying strategies during the capture step of downstream purification.