C18 Columns Expand Methods Development Toolbox
The flexibility to perform separations without pH, temperature or mobile phase restrictions arms chromatographers with powerful tools for tackling tough separations.
WHITE PAPERS & CASE STUDIES
Alternative Technologies For Cell Culture Clarification Efficiency
Production of therapeutics and diagnostics by cell culture processes has become the cornerstone of the biotechnology industry. Cell culture systems can consist of bacterial, yeast, insect or mammalian cells, with mammalian cell culture production becoming the most widely used method. By 3M Purification Inc
How To Maintain The Same Elution When Scaling A Separation Volume To Column Volume
In order to maintain the same elution pattern when scaling a separation between columns of the same phase but different inner diameters, gradient volume must be scaled in proportion to column volume.
When Powders Fail To Flow
There are many traditional measurement methods for characterizing the “flowability” of powders: angle of repose, flow cup, tap test. Practitioners know that the information may not be useful some of the time, but experience helps to separate the meaningful test results from those that may be suspect.
Rapid Separation Of Basic Drug Compounds Under Alkaline pH Conditions On pH-Stable, Short .C18 Column
Mobile phase pH is a powerful tool in methods development, particularly for separation of neutral forms of amines or other organic bases under alkaline conditions. By Derek Jensen and Mark Carrier, Hamilton Company
Improving DNA Removal from Bioprocess Purification Processes
Many new biological drug products produced using recombinant DNA technology, such as monoclonal antibodies, are produced in cell culture. Because therapeutic proteins such as monoclonal antibodies are produced in cell culture, impurities can result from the host cells, or cell substrates. By 3M Purification Inc.
Integrating Electronic Systems In The Clinical Trial Process
What exactly is an integrated electronic system for clinical trials? Though the term means different things to different people, there are some basic similarities on which the industry can agree