Tapping Into Metabolites To Overcome R&D Challenges And Develop Novel Biomarkers: Part 1
As we continue to strive to mine the genome for clues that can assist in understanding susceptibility to disease, selection of better targets for combating disease, and the biomarkers delineating response, a key source of data that can either lead or strengthen this pursuit is not always part of this equation. So what is this data and why would one ever exclude it?
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An Environmental Life Cycle Assessment Comparison Of Single-Use And Conventional Bioprocessing Technology
Biopharmaceutical development and manufacturing demand scalable processes that can be smoothly transferred to production. These processes need to be quickly developed and easy to implement.
Are You Into Biosimilars?
Biosimilars are considered to be one of the fastest growing sectors of the pharmaceutical industry.
Reduce Cost, Increase Quality, And Shorten Cycle Time In Upstream Manufacturing Scale Cell Culture With A Single-Use Heat Exchanger
Manufacturing biopharmaceutical products on an industrial scale has required scaling up a variety of techniques that were previously only practiced at bench scale. This includes highly technical and notoriously difficult processes such as cell culture; maintaining living cells in a tightly controlled sterile environment.
Navigating In The Single-Use Space: How To Find The Right Cell Culture Bioreactor
The bioreactor is the cornerstone on which cell culture for biopharmaceutical production is based.
Skip Steps In Cell Culturing
With Cell Culture Flask Adapters, the culture can be centrifuged directly in the flask. Data illustrates that cell yield, cell viability, and endpoint analysis results are comparable when cell cultures are processed traditionally or centrifuged directly in the flask using Cell Culture Flask Adapters.
Analysis Of Dialyzed Flask Technology For Antibody Production
Efficient and cost effective hybridoma culture is essential to small and large scale monoclonal antibody production for research purposes. By Denis Phichith, PhD and Brian Canna, MBA
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Cell culture is a complex, highly structured process for growing cells, under strictly controlled conditions, outside of their normal environment. Cell cultures stilluse cultures of cells on flat plastic dishes.
This is referred to as two-dimensional (2D) cell culture. Aside from using Petri dishes for growing cells, scientists have for a long time, grown cells within biologically-derived matrices such as collagen or fibrin.
Today, more and more 3d cell cultures are being used because they more closely resemble the in vitro cell growth environment. Most 3d cell cultures in use today are designed for stem cell research, tissue engineering and drug discovery. As the field continues to grow and expand, 3d cell culture availability will likely expand to include other cell culture related fields.
For non-adhesive cells suspension cell cultures are used. In these cultures a cell is placed in the liquid suspension, stirred with a magnetic stirrer to agitate the cell and make it float freely in the suspension. The cell grows, divides and spreads throughout the suspension.
Cell culture refers to the culturing of cells derived from multi-cellular eukaryotes (cells with a nucleus), primarily animal cells. However cell cultures also exist for plants, fungi and microbes that include viruses, bacteria and microorganisms. Cell culture shares closely related methodology with tissue culture and organ culture.
You can separate cells from tissues for use in cultures several ways. Cells can be purified from blood but only white cells will grow in a culture. Mononuclear cells can be released from soft tissue using enzymes that break the cells away from their substrate or matrix. Pieces of tissue can also be placed in a growth media and the cells that grow from it can be used for cell cultures.