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The Pall UpScale Program offers the most comprehensive range of products to support your applications from drug discovery and basic research through process development and production. The UpScale Program product line includes a range of filtration devices with identical membranes and similar materials of construction to minimize any process variation due to filter changes when the processing volume increases.

PreFilters

Profile II Capsule Filters

Pall Profile II filters provide absolute removal ratings for reliability, built in prefiltration for economy, and special construction for extended service life and high flow rates.
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Preflow Capsule Filters

Pall Preflow filters have been expressly designed to bring a significant improvement to prefiltration technology. The filter media utilized is based on our expertise in manufacturing rugged resin-bonded glass fiber composites.
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HDC II Capsule Filters

Pall HDC® II all-polypropylene capsule filters incorporate proprietary HDC II tapered pore polypropylene depth media. HDC II filters are well suited for a broad range of fine particle and prefiltration applications where purity, economy, and reliability are critical.
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Profile Star Filter Cartridges And Mini Profile Capsules

To keep pace with advancing technologies, Pall continues its tradition of filtration innovations with the Profile® Star filter, a state-of-the-art pleated polypropylene filter. With their large surface area, Profile Star filters are preferred when high flow rates are needed.
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Membrane Filters

Supor Membrane Capsule Filters

Supor® EKV polyethersulfone membrane filters are validated, 0.2 µm sterilizing-grade filters that offer an optimized built-in proprietary asymmetric technology prefiltration layer for longer filter life and lower filtra­tion costs.
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Fluorodyne II Membrane Filter Capsules

Pall Fluorodyne® II filters feature a unique hydrophilic modified polyvinylidene fluoride (PVDF) membrane with ultra low-binding properties, broad chemical and temperature resistance, and higher flows than competitive PVDF or other membrane cartridges.
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Ultipor N66 and Posidyne Membrane Capsules

Ultipor® N66 sterilizing-grade filter cartridges feature double-layer pure Nylon 6,6 membranes for higher assurance of sterilization. In wide use for almost 20 years, these filters have a proven record of perfor­mance in the production of sterile biologicals and pharmaceuticals.
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Ultipor VF Membrane Virus Removal Capsules

Pall Ultipor® VF virus removal filter grade DV50 and DV20 cartridges feature innovative hydrophilic PVDF microporous membranes to remove significant levels of viruses from biological solutions, while enabling high protein transmission.
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Technical Services

Disposable Filtration System Validation

Disposable filtration systems typically consist of disposable components such as capsule filters, aseptic connectors, bags and piping or tubing. As an integrator of disposable systems, Pall can provide reliable validation assistance to the users of disposable systems.
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DNA Qualification

Along with the availability of improved membrane purification technologies related to contaminant clear­ance for the production of biomolecules from mammalian cell culture, Pall has developed methodologies for the quantification of DNA in order to validate DNA clearance.
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Process Proteomics Services

Process Proteomics is a new approach to pharmaceutical, vaccine, and diagnostic molecule process development. Employing Ciphergen's ProteinChip technology, our Process Proteomics Service Centers provide the biotechnology industry with unique analytical tools that enable protein purification optimization and help driving biological products into the clinic more efficiently.
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Tangential Flow Filtration

Membranes Available in Cassette Format

Pall offers four membrane types with superior performance and stability to meet the challenges of each unique TFF application. Membrane Types include: Omega™, Alpha™, Regen™, and Supor® TFF mem­branes.
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Choosing The Right Cassette Format

Pall offers a broad range of membrane cassettes for TFF to cover the growing range of potential applications and process volumes. It is important to consider your specific requirements in order to select the most appropriate cassette and format for your application.
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TFF Optimization and Scale-up Guidelines

Tangential flow filtration (TFF) is a rapid and efficient method for separation and purification of biomole­cules. It can be applied to a wide range of biological fields, such as: immunology, protein chemistry, molec­ular biology, biochemistry, and microbiology.
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Minimate Tangential Flow Filtration Capsules

The easy-to-use Minimate™ TFF capsule is a valuable tool for any laboratory requiring tangential flow filtra­tion of small process volumes. Sample batch sizes of up to 1 liter can be reduced to as low as 5 mL.
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Centramate and Maximate Membrane Cassettes

Centramate™ cassettes are perfect for laboratory scale and development TFF applications. Small area for­mats with 90 cm2 and 180 cm2 may be used with the LV Centramate holder for process volumes from a few liters down to a few milliliters.
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How To Order Membrane Cassettes

Choose a membrane type from ‘Membrane Type' (e.g., OS, AS, CS or PS). Choose a MWCO from ‘Available MWCOs for Ultrafiltration Membrane' or a µm rating code from ‘Available Micron. Choose a format code from ‘Cassette and Screen Formats' (e.g., C10, C11, or C12).
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Centramate and Maximate Membrane Cassette Holders

Designed for optimum performance and product recovery Pall TFF cassette holders are available in a vari­ety of sizes to meet every application requirement. This way applications that are developed on a small system using a Centramate™ or Maximate™ cassette can be easily scaled up.
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Microza Membranes for Biotech Applications

Microza ultrafiltration membranes are unique in their construction. Each membrane has an asymmetric structure with a membrane layer on the inside and on the outside of the fiber. This structure is supported by an open core with excellent flow characteristics.
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Minim™ II Tangential Flow Filtration Systems

The Minim II system provides a platform for conveniently performing TFF processing (concentration, diafiltration, clarification) using very small sample volumes. This sanitary system helps to simplify process development and saves time and product during drug discovery, basic research, or small scale production.
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Chromatography Technology

Sorbent Selection Guide

Whether your application challenges are in research, scale-up or polishing, Pall offers an extensive portfolio of products for affinity, ion exchange, size exclusion, hydrophobic interaction and hydroxyapitite chromatography.
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Mustang Chromatography Capsules and Cartridges

Combining high-capacity ion-exchange Mustang® membranes with a unique 16-layer pleat design results in high flow rate, high-capacity, single-use, versatile, range of pleated products that can be used for a wide range of applications.
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Q, S, DEAE, CM Ceramic HyperD F, 20 Sorbents

Ceramic HyperD ion-exchangers are high capacity sorbents specially designed for the efficient and scalable purification of biomolecules from a variety of feedstocks. Of particular value in process-scale applications, these sorbents are designed to maintain high dynamic binding capacity (DBC) under conditions where conventional sorbents display significant capacity or productivity limitations.
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MEP HyperCel Ligands

Hypercel™ is composed of cellulose matrix to which the ligand is linked. The cellulose bead confers high porosity, chemically stability and low non-specific interaction.
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PKL Chromatography Systems for Process Development

The suite of PKL bench-top chromatography systems is designed for rapid method and process develop­ment across a broad spectrum of biotherapeutics such as proteins, peptides, plasmids, and viruses.
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