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Process Development Services
Cherokee Pharmaceuticals LLC
Gram to Kilo scale process development can be conducted on site by combining the capabilities of the engineering and process development laboratories. Experience in antibiotics, and highly toxic compounds are augmented by state of the art equipment and containment where needed.
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•Datasheet: Cherokee Research & Development Services
Gram to Kilo scale process development can be conducted on site by combining the capabilities of the engineering and process development laboratories. Experience in antibiotics, and highly toxic compounds are augmented by state of the art equipment and containment where needed.
•Datasheet: Cherokee Research & Development Services
•Datasheet: Cherokee Research & Development Services
Gram to Kilo scale process development can be conducted on site by combining the capabilities of the engineering and process development laboratories. Experience in antibiotics, and highly toxic compounds are augmented by state of the art equipment and containment where needed.
Building 402 Process Development Laboratory:
- Construction completed: 2000
- 4 Process development laboratories
- 5 Fume hoods ea. (4 – 6' and 1-2')
- Support areas for material storage and analytical support
- Analytical Laboratory
- 2 Fully instrumented high pressure cubicles (hydrogenations, carbonylations, etc.)
Equipment & Instruments
- 24 HPLCs, 1 preparatory scale liquid chromatograph, 1 LC/MS
- 2 Ion chromatographs
- 8 Gas chromatographs, 1 GC/MS
- 300 MHz NMR spectrometer
- Energy dispersive X-ray fluorescence (EDXRF)
- FTIR
- FTIR microscope
- TOC analyzers
- Microtrac particle size analyzer
- Optical microscope
- 4 - CINC semi-continuous liquid – liquid extractors
- Misc. instrumentation (e.g. titrators, coulometers, pH meters, balances, etc.)
- Low temperature (-20 oC) storage
Building 402 - Engineering Laboratory
- Construction completed: 2003
- Size: 1,700 ft2
- Maximum vessel capacity: 100 liter (glass)
- 2-Story hood (18'x20')
- Sland hood (14'x8')
- Laminar flow hood
Equipment & Instruments
- 1 liter to 50 liter sized jacketed reactors
- High pressure (autoclave) reactor
- Distillation columns
- Pocket filter, plate and frame filter press and basket centrifuge for filtration studies
- podbielniak extractor for continuous extraction studies
- 4 High capacity re-circulating heating/cooling services
- Rotary evaporators, batch and continuous
- Membrane separation skid
- Freeze dryer
- Zwag filter-dryer for kilo scale filtration and drying studies
- Specialized instruments and equipment such as Labmax for precise reaction and crystallization studies, Lasentec for particle size measurement, high-shear mixer for mixing studies
- Analytical capability to conduct most routine analysis (HPLC, GC, KF etc.)
- Low temperature (-75 oC) storage
Building 325 Development and Pilot Laboratories
- Construction completed 1995
- Dedicated to highly toxic, agricultural and veterinary compounds
- Containment includes administrative and engineering controls such as waste containment, waste detoxification
Development Laboratories:
- Three small scale development labs
- Each contain 4 - 6' fume hoods
Pilot Laboratory:
- Size: 600 ft2
- Electrical classification (Class I, Div I, Group B)
Process Development & Piloting
Kilo Scale cGMP Production / Engineering Laboratory
- Bench-scale & large glassware piloting up to 100 L
- Kilogram-scale production of pharmaceuticals
- Process-Safety Lab (under development)
B-402 Process Development Laboratories
- Lab scale chemistry and analytical development
B-325 Specialty Products Facility
- Highly toxic, high potency compound handling
•Datasheet: Cherokee Research & Development Services
