Products and Services
Oligonucleotide And Peptide Synthesizers
•Brochure: Oligonucleotide And Peptide Synthesizers
•Brochure: Oligonucleotide And Peptide Synthesis Columns
TechniKrom® provides pilot and production scale (10 µmol – 1 mol) automated synthesis units for use in the Biopharmaceutical, Pharmaceutical and Fine Chemical Industries.
Our Synthesizers are custom built around our standard technology platform and designed in accordance with GAMP-4 guidelines to meet client User Requirement Specifications, accommodating the specificity common with most synthesis needs. Synthesizers are designed for amino acid or amidite use with appropriate solvents and reagents, depending upon application. A variety of compatible Materials of Construction (MOC) are available including 316L ss, Hastelloy Alloys and a full range of polymers which can be utilized to withstand the demanding environment of synthesis.
TYPICAL FULLY AUTOMATED BIO-SYNTHESIZER:
The unit is sanitary, cGMP designed, portable skid mounted system with low dead volume path appropriate for both multi-product and dedicated cGMP syntheses. Features normally include, but aren't limited to those indicated below.
- Solvent and acid/base resistant 316L stainless steel or polymeric tubing, fittings and valves.
- Low dead volume controlled inlets for reagents, amino acids, amidites, and solvents.
- Triple Head Teflon Diaphragm Metering Pumps: Appropriate pump sizes with turndown capability, stroke length adjustment, variable frequency drive and high precision industrial design features.
- Flowmeter(s) downstream of pumps to provide feedback to keep flow rate accurate while submitting real time flow rate documentation into batch reports.
- Pressure sensor and transmitter holds a specified setpoint and enables emergency alarm and system pause for high-pressure condition.
- Automatic, resumable, safety pause of system in case of user-defined alarm.
- Outlet manifold is of sanitary low dead volume design for automated reactor vessel/column bypass and waste; minimizes carry over and facilitates system cleaning.
- Post-reactor conductivity detector in a sanitary flow cell to provide automatic logging of conductivity data.
•Brochure: Oligonucleotide And Peptide Synthesizers
•Brochure: Oligonucleotide And Peptide Synthesis Columns
