Liquid-Filled Hard Capsules (LFHC)

Source: Patheon Inc.

Details

Patheon's Liquid-Filled Hard Capsule development and manufacturing services meet the formulation challenges facing many of today's complex molecules. Two-piece Liquid-Filled Hard Capsules (LFHC) are an ideal solution for low-solubility molecules, high-potency molecules, and those susceptible to oxidation and exhibiting low melting points. Liquid-Filled Hard Capsules also provide increased content uniformity for low-dose products while minimizing consumption of Active Pharmaceutical Ingredient (API) during development.

Available in both hard gelatin and vegetable-based HPMC (hypromellose) capsule shells, LFHCs provide additional advantages over softgel capsules, including:

High temperature fill (up to 70°C)
Adaptability to multiple shell systems
Reduced water migration from shell to fill
Reduced fill component to shell migration
Development scale batch capability without special equipment
Easier validation (fewer critical process parameters)

Colorful liquid-filled hard capsule and banding options provide you with product branding opportunities for new or existing pharmaceutical products.

We utilize the experience and expertise of our scientists to rapidly formulate your liquid-filled hard capsule dosage forms allowing you to rapidly get your new molecule into First Time in Human (FTIH) clinical studies. With early development scale batches available at our Canadian and UK development centers and larger development and commercial batches available at our Cincinnati, USA site, we can rapidly scale your LFHC product in the quantities you need.

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