Small Scale Bioreactors White Papers & Case Studies

1. Process For Scale-Up Of Adherent Vero Cells From Static Cell Factories To Influenza Production 5/29/2013

   In cell culture-based vaccine production, scale-up of adherent cells is challenging. This study shows a process for scaling up adherent Vero cells from static cell factories to influenza production at 50 L scale using WAVE Bioreactor™ systems and ReadyToProcess single-use equipment.

2. Scale-Up Of Microbial Fermentation Using Recombinant E. Coli

   Fermentation production facilities can utilize the Thermo Scientific™ HyPerforma™ Single-Use Fermentor (S.U.F.) instead of traditional stainless steel cleaning-in-place/ sterilization-in-place (CIP/SIP) fermentor vessels without modifying their existing procedures.

3. Challenges And Solutions Of Scalable Cultivation For Anchorage Dependent Cells In Single-Use Bioreactor

   Microcarrier (MC)-based suspension culture processes have been used to culture anchorage-dependent cells in bioreactors. However, scale-up of the process for high cell growth and productivity poses many challenges. By Brian Lee, Yas Hashimura, Daniel Giroux, Marcos Sousa, Joao Clemente, Manuel Carrondo, Siddharth Gupta, Michael McCaman, and Yong-Jae Kim

4. Cultivation Of Aggressive Microbial Cultures Of Pichia And Bacillus

   Advances in single-use bioprocess technology have led to the rapid adoption of single-use bioreactors (S.U.B.s) across a broad range of applications within the biotechnology industry.