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Defining Hydrolysates: An Approach for Generating a Chemically Defined Alternative

Join us for a Complimentary Webinar on November 18

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In the biopharmaceutical industry it is common to see protein hydrolysates in cell culture processes as part of a complete medium formulation or a fed-batch bioreactor process. It is well documented that hydrolysates can have a substantial positive impact on cell growth and/or protein production. However, given the undefined nature and the lot-to-lot variability associated with hydrolysates there exists a need to mitigate these risks with a chemically defined (CD) alternative that can maintain the desired performance. SAFC Biosciences® is now offering a new product that meets this goal and can quickly convert an undefined process to fully defined. The approach to solving this complex puzzle is discussed within, including details on how "active" hydrolysate fractions were found and the subsequent identification of the compounds contained within. The knowledge gained from this work was used to design EX-CELL® CD Hydrolysate Fusion, which is capable of replacing the functions of hydrolysates in many Chinese Hamster Ovary (CHO) cell systems.

What you will learn by Attending:

  • Understanding of hydrolysate complexity and source of variability
  • Analytical technologies used to characterized undefined components
  • Impact of hydrolysate addition on CHO cell gene regulation and overall performance
  • Product scale-up considerations
  • Chemically defined application proofs


SAFC Biosciences develops, manufactures and markets cell culture reagents and services targeted for commercial firms involved in developing and producing biopharmaceuticals using mammalian and insect cell culture methods. SAFC Biosciences is focused on organizations involved in human therapeutics, animal health and diagnostics in various stages of development from preclinical through clinical phases I, II and III to marketed products. SAFC Biosciences has successful relationships with pharmaceutical, established biotech, start-up biotech, contract research and manufacturing organizations, agricultural-related and non-profit organizations. Our expertise allows us to offer our customers safe, productive and consistent products and services that improve speed to market. We recognize the importance of providing responsive service and unsurpassed quality in our products. We focus on tailored solutions and manufacturing processes designed to meet the specific needs of our customers. By developing strong relationships we can assist our customers in every detail of product selection, modification and customization.

The company has a 35-year history as a manufacturing partner providing leading biopharmaceutical companies with the broadest range of highly customized products and services possible. SAFC Biosciences has six production facilities in the United States, Europe and Australia, and employs 600 people.

SAFC Biosciences develops, manufactures and markets cell culture reagents and services targeted for commercial firms involved in developing and producing biopharmaceuticals using mammalian and insect cell culture methods.

We are focused on organizations involved in human therapeutics, animal health and diagnostics in various stages of development from pre-clinical through Phases I, II and III to commercialization. We have successful relationships with pharmaceutical, established biotech, start-up biotech and contract manufacturing organizations. SAFC Biosciences is the world's leading supplier of cell culture reagents to producers of marketed biological products.

Products/Services:

SAFC Biosciences' platforms include proprietary serum-free and classical media, sera and specialty products such as buffers, detachment factors, growth factors and protein components, supplements and reagents. We offer unique services related to small volume custom media as well as single-use disposable bioprocessing systems that provide upstream and downstream solutions for biologic processes.

Key to the SAFC Biosciences' offering is expertise in custom products and services, including development services for clone selection and optimization, cell culture media development and optimization, custom formulations and packaging.

We offer extensive regulatory, products and analytical support tied directly to customers' unique requirements. We have a proven track record in marketed biopharmaceuticals and are fully dedicated to customers' specific cell culture needs.

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Contact Information

SAFC Biosciences

11296 Renner Boulevard

Lenexa, KS  66219 

UNITED STATES

Phone: 913-469-5580

Fax: 913-469-5584

Contact: Bruce Lehr

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