Toxicity studies are an essential component of progressing compounds through the drug discovery process. Molecules must be screened for non-specific, adverse biological properties such as cytotoxicity. As a significant number of compounds fail during ADMETox due to their toxicity, it is of paramount importance to have an effective early indication of any compounds that exhibit cytotoxic effects. Click here to download the Fail-Early Approach To Compound Screening Using A Dual Nuclear Staining Assay Application Note

Genetix delivers the competitive edge in cell identification and selection, from discovery to diagnosis.

Genetix proven and continuing innovative ability has enabled us to develop a family of systems delivering step changes in the identification and isolation of, for example, therapeutic protein producing cells.

• Cell screening and selection
• Genetic testing and cancer pathology
• Protein science
• Microarraying
• Cell and liquid dispensing and a host of related reagents and consumables.

Through the acquisition of Applied Imaging Corporation, Genetix now offers the latest technologies for

• Imaging and isolating cells, DNA and proteins
• Automation-picking and placing robotics
• Reagents and consumables
• Dedicated software

Genetix is based in New Milton on England’s south coast, the site of all our research and development. The company also has offices in Boston and San Jose, USA, and Munich, Germany, as well as a network of selected distributors in other regions of the world.

Since the company’s foundation in 1991, Genetix achievements have helped revolutionize cell biology, proteomics and genomics.

• Genetix was the first company to commercialize the 384-well plate, now the industry standard.
  
• Both the human and rice genome sequencing projects relied on Genetix high-throughput colony picking systems. These were supplied to seven of the leading eight laboratories of the Human Genome Project.
  
• ClonePix the world’s first mammalian cell picker, launched in 2003.

In 2005, Genetix instrumentation facilitated the building of a functional human protein kinase repository. Protein kinase research accounts for almost a third of the early stage drug discovery work undertaken by the pharmaceutical industry.

Genetix CellReporter rapidly screens potential compounds for adverse biological effects resulting in only the lead compounds being taken onto high magnification, technically-demanding systems Click here to download the CellReporter brochure

The CloneSelectImager revolutionizes cell line management, measuring confluence and cell growth objectively and consistently, and performing rapid, detailed analysis of cells in a range of microplate and static culture formats. Click here to download the new Clone Select Imager brochure

Download the new Genetix 2007 Product Guide to discover more than 100 pages describing the Genetix breakthrough platforms. The guide is a valuable resource for the laboratory. ClonePix FL and CloneSelect Imager are presented along with dedicated reagents and consumables for the generation, selection and management of mammalian cell lines for biopharmaceutical and drug discovery. Applications described in the new guide, range from the stratification of cell populations based on growth rate, therapeutic protein secretion productivity or cell surface marker expression to automated confluence measurement and assessment of clonality. The Genetix product range also includes liquid handling systems for cell and media dispensing, colony pickers and automated microarray instrumentation."