L-Methionine sulfoximine (MSX) inhibits the activity of glutamine synthetase (GS), an enzyme essential for the production of glutamine. MSX can be used as a media supplement to aid selection and amplification processes in recombinant mammalian cell lines that use GS as a selective marker. 

Peptide therapeutics have been recognized as delivering the best of both worlds in terms of small molecule synthesis efficiency and biologics efficacy and reduced toxicity.

To address the growing demand for effective peptide purification, Grace has developed the new Vydac® 150HC purification media. 

In 2011, innovation was a major topic among the various players in the drug development industry. Feedback from clients and sponsor-side industry personnel prompted a change in the outsourcing drivers included in the Nice Insight Pharmaceutical and Biotechnology Outsourcing survey, such that innovation — or the ability to improve in-house capabilities with customized solutions — replaced accessibility for the 2012 research cycle. By Kate Hammeke, research manager, Nice Insight

Nearly 65% of biomanufacturers are planning to increase their budgets for new technologies to improve efficiencies and costs for downstream production, and three out of every five are increasing funding for new upstream production technologies. By Eric Langer, president and managing partner, BioPlan Associates, Inc.

Even with more than 8,800 employees and an annual budget of around $3.2 billion, the FDA’s task of protecting the public health seems daunting, considering the complexity of products being developed by industry. By Rob Wright

Imagine you spent the past 15 years of your life passionate about finding a cure for Alzheimer’s. You stayed up nights struggling to continue your research, yet you were running out of funding. Knowing your competitors were years behind your research, you finally found your angel investor who provided the seed capital you needed — but with the time-sensitive precondition that you must provide a return on investment within two years or they would pull your financing. By Jonathan Snyder

The TSI NanoScan SMPS Model 3910 opens the door to routine nanoparticle size measurements. This revolutionary sizer utilizes scanning mobility particle sizing technology in a portable instrument that is about the size of a basketball.

Flash chromatography is a fast and cost-efficient approach to purify synthetic peptides and other small molecules.

The proprietary RevealX™ detection technology of the Reveleris® flash chromatography system integrates multiple detector signals with advanced signal processing to recognize eluting compounds that previously were undetected by UV alone.