Downloads
Technical Note: Nuvia™ S Media — A High-Capacity Cation Exchanger For Process Purification Of Monoclonal Antibodies
Nuvia S is a high-capacity strong cation exchanger designed for optimal bioprocessing performance. It is built on the macroporous rigid UNOsphere™ base matrix, through the incorporation of polymeric surface extenders with optimized density of sulfonate groups.
This application note describes the effects of flow rate, load pH, and conductivity on the binding of polyclonal human immunoglobulin G (hulgG) and monoclonal antibodies (mAbs) by this new chromatographic media. Preliminary studies on the removal of product-related impurities using Nuvia S were also conducted.
The content you requested is only available to registered users of Bioresearch Online. By registering now, you'll get access to this piece of content and thousands of additional articles and product reviews across our entire network of sites.
