Alternative Technologies For Cell Culture Clarification Efficiency

The first step in the production of therapeutics and diagnostics by cell culture processes involves separating cell mass from the product.   Separation of the cell culture fluid challenges the process engineer to select a separation method that results in maximum product yield, complies with FDA regulatory requirements and offers acceptable economic performance.     

This 3M Purification, Inc. Application Brief presents how Zeta Plus™ depth filtration can be used to address the issues associated with tangential flow filtration (TFF) and centrifugation.   

• Zeta Plus depth filtration
• Tangential Flow Filtration (TFF)
• Centrifugation