By Wayne Koberstein, Executive Editor
The general impression when a drug fails is that it wasn't a good drug. Well, perhaps the chemists and formulators didn't get it wrong; the plain truth of it is this: Innovations don't just happen on the bench, they also happen in clinical trials.
By Thomas O'Brien, Ph.D., 3M Purification
Activated carbon in the pharmaceutical industry has been used for many years to reduce impurities derived from the reactions that create active pharmaceutical ingredients (APIs). The adsorptive properties and the very large surface area of activated carbon make it ideal for filtering impurities from APIs, with decolorization being the most common pharmaceutical application.
By Ray Rose, Stacey Willard, and Ma Sha
Packed-bed bioreactor cell culture is generally accepted as one of the best methods to simulate the conditions of animal cell growth in vivo, since cells are maintained in a low-shear environment with constant refreshment of nutrients and removal of waste.
Closed single-use systems reduce the risk of two critical forms of contamination: biological contamination and cross-contamination. Biological contamination includes competitive organisms, such as bacteria, fungi, and yeasts, that are inadvertently introduced into cell culture processes. These organisms utilize culture nutrients, produce unwanted proteins, and limit growth or destroy the intended cell culture. Most biological contaminations result in rapid growth and observable culture changes that indicate a culture must be discarded.
By Rob Darrington, Genevac
For many years, lyophilization, or freeze drying, has been used to dry samples in the laboratory. The technique is well researched, and has become the method of choice for many researchers with a few samples to dry. Lyophilization is often preferred because a high level of dryness is achieved with low residual solvent levels, and because of the light, powdery, 'fluffy' finish of the sample, which enables the sample to be easily removed and weighted out.
INTERPHEX is the single source for complete biopharmaceutical and pharmaceutical manufacturing solutions to confidently process all dosage forms of life-enhancing drugs. See, touch, and procure the latest technologies and innovations, March 18 to 20, 2014, at the Javits Center in New York City. For more information visit www.INTERPHEX.com.