Newsletter | February 19, 2014

02.19.14 -- U.S. Biomedical R&D Demise

Bioresearch Online Newsletter
Downstream Upstream Quality/Regulatory Supply Chain Integrity
» Featured Magazine Article
Reports Of U.S. Biomedical R&D Demise: A Great Exaggeration
By Rob Wright
Prior to heading out to the 32nd Annual J.P. Morgan Healthcare Conference in San Francisco last month, I stumbled across several article headlines indicating the United States's domination of global biomedical R&D was fading. What metric was used to determine this? R&D spend. According to “new” research from the University of Michigan Health System, the U.S. share of the global biomedical R&D business declined from 51 percent to a mere 45 percent from 2007 to 2012. And while Europe remained unchanged at 29 percent, Asia rose from 18 to 24 percent.
Featured Focus: Downstream
The Challenging Requirements Of Integrating Disposable Sensor Technology
By Karl Schick, Innovation Manager
Sensors designed for incorporation into disposable purification platforms, i.e. single-use tangential flow filtration (TFF), single-use normal flow filtration (NFF), or disposable chromatography, must meet a number of challenging requirements.
APPLICATION NOTE: Options For Shortening Integrity Test Time Of Sterile Filters
WHITE PAPER: Get Fast And Efficient Purification Of Weak Nonchromophoric Lipid-Based Compounds
SERVICE: Freeze-Drying Formulation Development Services
PRODUCT: Mix-Mode Chromatography Media
PRODUCT: Single-Use BioProcess Container Bags
» Upstream
APPLICATION NOTE: Scalable Expansion Of Human Pluripotent Stem Cells In A Single-Use Bioreactor
By Ruth Olmer, Christina Kropp, Claudia Huether-Franken, and Robert Zweigerdt
The routine application of human pluripotent stem cells and their derivatives in regenerative medicine and innovative drug discovery will require the constant supply of high cell numbers in consistent high quality.
WHITE PAPER: Analysis Of Dialyzed Flask Technology For Antibody Production
By Denis Phichith, Ph.D., and Brian Canna, MBA
Efficient and cost-effective hybridoma culture is essential to small-scale and large-scale monoclonal antibody production for research purposes.
DATASHEET: Genderless Connector For 1/4" To 3/4" Sterile Connections
By Colder Products Company
DATASHEET: Pure Sericin: Silk Protein
By Wako Laboratory Chemicals
BROCHURE: EX-2000 Gas Analyzer For Fermentation
POSTERS: Automated Fluorescence Detection And Imaging Of RNA Species In Live Cells
SERVICE: Auction And Sales Services Of Pharmaceutical And Biotechnology Equipment
» Quality/Regulatory
ARTICLE: How To Turn The TMF Into A Strategic Asset
By Jennifer Goldsmith, VP of Vault, Veeva Systems
According to a 2012 Trial Master File (TMF) Reference Model survey of 500 sponsors, CROs, and consultants, 28 percent of respondents are currently using an electronic TMF (eTMF) while 57 percent are in the process of planning, building, or evaluating an eTMF — a 12 percentage point jump since 2010. Most eTMFs today are used like electronic filing cabinets, merely a scanned archive of TMF information. Only a small fraction leverage the eTMF's ability to deliver business insights that provide true strategic value to the organization.
WHITE PAPER: Don't Get Blindsided By New USP Quality Standards
By Dirk Ahlbrecht, Sartorius Group
The U.S. Pharmacopeial (USP) Convention's Chapter 41 minimum quality standards for weights and balances have been updated after twenty years — and every pharmaceutical manufacturer is waiting to see what that means in practice.
DATASHEET: Integrity Powder Transfer Vessels 
By ATMI LifeSciences
CATALOG: 3M Products And Services For Medical Sterilization Processes
BROCHURE: Isomedix Contract Sterilization Services
PRODUCT: miVac Quattro Sample Concentrator
» Supply Chain Integrity
ARTICLE: Complex Cold-Chain Integration Made Simple
CASE STUDY: Genesis Genetics Saves More Than 50 Percent In Shipping Costs With Passive Packaging Solution
CASE STUDY: Marken Delivers In Spite Of A Dry Ice Disruption In Moscow
DATASHEET: VL2000 Temperature And Humidity Loggers Datasheet
By Vaisala, Inc.
PRODUCT: Clinical Trial Cold Chain Logistics
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