Interested In Improving Cell Culture Cell Clarification Efficiency?
The first step in the production of therapeutics and diagnostics by cell culture processes involves separating cell mass from the product. Separation of the cell culture fluid challenges the process engineer to select a separation method that results in maximum product yield, complies with FDA regulatory requirements, and offers acceptable economic performance.
See how depth filtration can be used to address the issues associated with tangential flow filtration and centrifugation.
By Ed Miseta, Chief Editor, Outsourced Pharma and Clinical Leader
In the late 1970s and early 1980s, the home video game industry was ruled by Atari. The company, started in 1972, saw its share of the video game market grow to 80 percent in just 10 years. Purchased for $28 million in 1976, Atari saw its net worth grow to $2 billion by 1982. But in 1983, when the industry hit a slump, the company lost $536 million and reportedly performed a mass burial of games and game systems at a landfill in Texas. After several acquisitions and name changes, the Atari brand is likely unknown to most of today’s young gamers. When not paying attention to the wants of customers, even a dominant firm in an industry can lose its way.
By Christine Park, Quality Architech
In 2002, the FDA announced an initiative to integrate quality systems and risk-management approaches into existing regulations for pharmaceutical manufacturing. While the FDA hasn’t changed the 21 Code of Federal Regulations (CFR) Parts 210 and/or 211 regulations, they have published industry guidance, Quality Systems Approach to Pharmaceutical CGMP Regulations.
By Iftekhar Ahmed, Ben VanderPlas, and Stu Krupnick, ThermoSafe, Sonoco Protective Solutions
Bulk transportation of temperature-sensitive pharmaceuticals and biologics has become a common practice, due to complex global supply chains.
By Peter J. Brescia, Applications Scientist, BioTek Instruments, Inc.
Here we demonstrate the use of a fluorescent polarization assay using SET7/9, a SET domain-containing mono-methyltransferase, as a model system suitable for HTS applications in a 384-well microplate format using automated methods and a HTS microplate reader.
By Bopanna N.K., Chitra Sundararajan, and Melissa J. Wilcox, Grace Discovery Sciences
Peptides and proteins are becoming increasingly popular for their potential use as therapeutic drugs. To earn and maintain a share in the fast-growing peptide market, peptide researchers and manufacturers are constantly trying to improve and optimize the various steps in peptide synthesis.
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