Syloid® FP Silicas For Oil AdsorptionSource: Grace
Syloid® FP silicas are mesoporous, amorphous, and micronized silica gels that are used as excipients in many pharmaceutical formulations, due to their unique morphology. The combined adsorption capacity, porosity, particle size, and large surface area allow them to provide several benefits simultaneously, which can expedite manufacturing and improve efficacy of the final dosage form.
Oils are used in pharmaceutical formulations to improve taste, prepare stable suspensions of drugs, add stability to APIs that are sensitive to hydrolysis, and in various other applications. In addition, oils are increasingly being used in formulations today as drug solubilizers, adsorption enhancers and vehicles for lipid based drug delivery, in order to increase the oral bioavailability of poorly soluble drugs. The main challenge in oil-based formulations is converting oily solutions and liquid formulations into compressible solid or semi-solid formulations.
Syloid® FP silicas are an excellent carrier for converting oils, oily drugs, and drugs in oil solutions into free flowing powders. They can be used as adsorbents in techniques such as solid dispersion, semi-solids and in lipid-based technologies such as self-emulsifying drug delivery systems (SEDDS).
Adding Syloid® FP Silica Can Help In:
■ Retaining aromas and tastes
■ Preventing sticking to machinery
■ Preparing stable suspensions
■ Converting liquids to powders
■ Solutions for lipophilic APIs
■ Carrying oily drugs