Disposable products continue to be a hot topic in biomanufacturing, as they increasingly penetrate clinical- and commercial-stage manufacturing and are sought after for their process efficiencies. In fact, when we asked the 450 global subject matter experts and senior participants on our Biotechnology Industry Council™ to identify the critical trends in bioprocessing for 2013, 22% cited aspects associated with implementation of single-use system integration. These ranked narrowly behind need for downstream processing optimization, and analytical methods development (each at 24%). Read more.
In the following tutorial, ATMI LifeSciences offers an overview of the different technologies available to the market for scaling up stem cells, as well as a look into what factors affect the type of technology you should use. Learn more.
Closed Systems For Small-Scale, Single-Use Applications
A Q&A With Brent Bushnell, Colder Products Company
Closed single-use systems reduce the risk of two critical forms of contamination: biological contamination and cross contamination. Biological contamination includes competitive organisms, such as bacteria, fungi, and yeasts, that are inadvertently introduced into cell culture processes. These organisms utilize culture nutrients, produce unwanted proteins, and limit growth or destroy the intended cell culture. Most biological contaminations result in rapid growth and observable culture changes that indicate a culture must be discarded. Read more.
Perfusion And Single-Use Bioreactors: A Partnership For Scale Up
By PBS Biotech, Inc.
Perfusion has emerged as a viable technology for the commercial production of biopharmaceuticals. Perfusion solutions can offer very cost-efficient scale up solutions, driving down operating costs, due to the smaller equipment and facilities needed compared to batch or fed-batch systems. Read more.