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05.28.14 -- Sanford-Burnham and Daiichi Sankyo Enter Drug Discovery Alliance; Innovation In Alternative Chromatography

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Announcing Process Separations Webinars

Announcing Process Separations Webinars

Using Mixed-Mode Selectivity To Address Purification Challenges
Learning objectives:

  • Understanding mixed-mode chromatography basics and how to modulate ligand/protein interactions
  • Developing methods with the least amount of experimentation
  • Address difficult purification challenges using new selectivity
Process Intensification Using Modern Chromatography Media
Learning objectives:
  • Developing purification process with fewer chromatography unit operations
  • Reducing feed manipulation and buffer consumption for a more compact process
  • Exploiting novel selectivity to address purification challenges
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Featured Content

Magazine Article: Innovation In Alternative Chromatography
By Eric Langer, president and managing partner, BioPlan Associates, Inc.
For years, many biopharma industry manufacturers have said the use of Protein A chromatography for purifying biologics (a mainstay process) isn't broken, so why fix it? However, Protein A media remains a major thorn in the side of operators due to its high cost, as well as the cost of recycling and cleaning/validation. Alternative technologies for purification of antibodies have been and are being developed with longer lifetimes and therefore, lower cost-per-unit of protein produced.


Application Note: Monoclonal Antibody Purification With A High-Capacity Protein A Resin
By TOSOH Bioscience LLC
TOYOPEARL AF-rProtein A HC-650F, a high-capacity protein A resin for the purification of monoclonal antibodies (mAbs), was recently introduced by Tosoh Corporation. This resin, with dynamic binding capacities (DBC) of 70 g/L at 5 minutes residence time, is the newest member of the TOYOPEARL product line.


Article: Efficient and Cost-Effective Removal Of Residual Endotoxin
By Ben Galarza, Jason Shipp, Buzz Lobbezoo, Jennie Walden and Steve Burton, ProMetic BioSciences Ltd
Endotoxin or lipopolysaccharides (LPS) are highly toxic components of the cell wall of Gram-negative bacteria and are often present in significant amounts in bacterial cell culture expression systems such as E. coli.


White Paper: Effect Of Sterilization On Mechanical Properties Of Silicone Rubbers
By Emilie Gautriaud, Keith T. Stafford, Jennifer Adamchuk, Mark W. Simon and Duan Li Ou, Saint-Gobain, Northboro R&D Center
Silicone rubber is widely used in the pharmaceutical industry where sterilizability is an essential requirement for all fluid transfer equipment. Pharmaceutical products must be sterilized frequently and repeatedly by high level energy and/or chemical vapor in order to eliminate bacterial surface contamination.

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Gain the insight and contacts you need to make your single-use platforms more efficient, economical, and meet more complex drug demands at IBC's 11th Single-Use Applications for Biopharmaceutical Manufacturing conference, taking place June 9 and 10, 2014, in Boston, MA.
Bioresearch Online readers can save 20 percent off the standard rate with priority code B14187BIO20 during online registration at http://bit.ly/1jHaZ86.

 

Upcoming Training

 


CRA Oversight — A Risk-Based Approach
Date: Tuesday, June 10, 2014 • Time: 1pm – 2:30pm EST

The Future Of Biosimilars: Addressing Regulatory Challenges
Date: Thursday, June 19, 2014 • Time: 1pm – 2:30pm EST

Featured Downloads

Modular Mixing And Docking System: imPULSE MD
The imPULSE MD puts superior mixing and modularity into your process. The motor drive carts and the vessels interlock for mixing and easily separate to keep your process moving.

MPC Ceramic Hydroxyfluoroapatite Chromatography Media Brochure
MPC media, a composite of hydroxyapatite and fluoroapatite (Ca10(PO4)6(OH)1.5(F)0.5), is a complementary addition to our line of ceramic apatite mixed-mode chromatography media.

ÄKTA start: Chromatography System For Lab-Scale Protein Purification
ÄKTA start is a preparative chromatography system for laboratory-scale protein purification.

Liquid Handling Solutions Catalog
Selecting the right fluid-handling components for your device is critical. Parts that are unreliable or do not perform as promised can alter instrument performance, delay market release, greatly increase field service costs, and jeopardize the relationship with your customer.
Browse the download library

Featured Multimedia

AseptiQuik STC Connectors
AseptiQuik STC Connectors integrate the AseptiQuik sterile connector and the Steam-Thru II SIP connector, giving manufacturers even greater flexibility for hybrid stainless steel and single-use processing.

Bulletin Board

Delivering Biologics With A Difference
As the biologics market continues to grow, with additional launches, expanding indications, and approvals of biosimilars, the delivery platform will play a more critical role in product differentiation.

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Chromatography Consumables Every Lab Needs
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Allegro STR 200 Single-Use Stirred Tank Bioreactor
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Metastasis Inhibitor: MI-22
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