Reduced Cost-Per-Run For Oligonucleotides Purification

Source: Hamilton Company

New 3 µm PRP-h5 HPLC columns from the Hamilton Company are designed for the purification of oligonucleotides. The cost-per-run is dramatically reduced as the desired oligonucleotide elutes with less acetonitrile because the PRP-h5 packing material is less hydrophobic than traditional polymeric columns. The stronger hydrophilic backbone of PRP-h5 virtually eliminates non-specific binding of oligonucleotides to maximize recovery and minimize carry-over contamination from the previous injection. Also, PRP-h5 is available in 10 µm preparative columns and your choice of 30 µm to 50 µm bulk material for sample preparative applications. The new PRP-h5 columns are pH stable from 0 to 14 and easily accommodate a broad range of organic solvents.

SOURCE: Hamilton Company