Bisphosphonates are a group of compounds that are used as active pharmaceutical ingredients (APIs) to treat bone disorders including osteoporosis, Paget’s disease, and hypercalcemia. Typical methods for bisphosphonates analysis include liquid chromatography (LC) with derivatization and/or ion pairing, ion chromatography (IC), capillary electrophoresis (CE), and gas chromatography (GC) with derivatization. Read more.
KANEKA KanCapA: A New mAb Purification Platform
By Kazunobu Minakuchi, Masahiro Funaki, Hiroaki Kawasaki, Alan Walker, Francesco Liotino, and Dirk Hoegaerts
The C domain of Native Protein A binds to the Fc region of an antibody, but also binds to the Fab region, especially to the VH3 subfamily of mAbs. This type of binding requires a more acidic pH for elution. Read more.