PRP™-C18 Reversed-Phase HPLC ColumnsSource: Hamilton Company
The Hamilton PRP™-C18 is a new HPLC column designed to provide high-efficiency, reversed-phase separations over an extended column life in nearly any mobile phase or pH.
High-Efficiency Separations at Any pH
The Hamilton PRP™-C18 is a new HPLC column designed to provide high-efficiency, reversed-phase separations over an extended column life in nearly any mobile phase or pH. The rigid stationary phase has excellent mechanical and thermal stability, does not experience shrinking or swelling, and is completely inert to most conditions commonly encountered in reversed-phase chromatography.
The Hamilton PRP-C18 Column is a durable and effective column for general purpose HPLC and is especially well-suited for specialized applications in the clinical, pharmaceutical, environmental, food, forensics, and life sciences industries.
The PRP-C18 column has similar mechanical stability and separation efficiency to that of a traditional octadecylsilane (ODS); however, the PRP-C18 stationary phase does not strip, bleed, or dissolve under the most extreme conditions (e.g., pH 1–13, temperatures > 100°C). It will perform reliably and reproducibly throughout an extended column lifetime, regardless of mobile phase conditions. These characteristics allow for an expanded mobile phase repertoire for use in methods development or aggressive regeneration procedures.
Benefits of the PRP-C18 HPLC Column:
- Excellent mechanical and thermal stability (> 100°C)
- Can be regenerated in high acidic or basic concentrations (1 M)
- High-efficiency reversed-phase separations in nearly any mobile phase or pH
- Performs extreme application not possible with traditional ODS C18 columns