Bioprocessing Product Highlights

ActiCHO Media System

The ActiCHO Media System for easy feeding and easy scale-up provides high performance, high protein yield, and speeds up the process significantly.  Fed-batch culture improves the yield and the concentration of highly active recombinant proteins by continuous supplementation with essential nutrients.

Features of the ActiCHO Media System include:

• Ready-to-use starter kit and scale-up kit
• Chemically defined
• Significant increase in productivity
• Production of proteins with high potency
• Speeds up time to market

WAVE Bioreactor™

WAVE Bioreactor™ 200 and 500/1000 systems are ready-to-use products. The system is a cell culture device for the production of recombinant proteins in mammalian and insect cell lines in batch, fed-batch, and perfusion culture.

WAVE Bioreactor 200 and 500/1000 systems deliver:

• Presterilized, single-use Cellbag bioreactors, require no cleaning, minimal validation
• Cellbag bioreactors are supplied sterile and ready for use and suitable for cGMP commercial production
• Multiple instrument configurations for suspension, microcarrier, batch, fed-batch, or perfusion culture
• Capable of handling culture volumes from 500 mL to 500 L

PreDictor 96-Well Filter Plates

PreDictor 96-well filter plates are prefilled with GE Healthcare BioProcess chromatography media. PreDictor plates support high-throughput process development (HTPD) by allowing parallel screening of chromatographic conditions, either in a manual or in an automated workflow. 

Shortens time-to-clinic and increases productivity by: 

• Reduced experimental time
• Low sample consumption
• Increased process understanding

MabSelect SuRe LX

MabSelect SuRe LX is an alkali-stabilized, protein A-derived affinity medium with a binding capacity for monoclonal antibodies (MAbs) exceeding that of MabSelect SuRe at longer residence times. This special combination of high binding capacity plus alkaline stability gives manufacturers of MAbs many opportunities to improve process economics and product quality. 

Capto ImpRes 

Capto SP ImpRes and Capto Q ImpRes are strong cation and strong anion exchangers for the high-throughput intermediate purification and polishing steps of a wide range of biomolecules.

Benefits:

• High-resolution intermediate purification and polishing based
• Flexible process design
• Easy to optimize and scale up
• Higher manufacturing productivity
• Security of supply and comprehensive regulatory support 

ÄKTA

ÄKTA avant is a preparative chromatography system designed for rapid and secure development of scalable chromatographic methods and processes. ÄKTA avant offers a complete solution for rapid, high-quality protein separations while maintaining flexibility and reliability.

Capto L

Capto L is an affinity chromatography medium for the process-scale capture of a broad range of antibodies and antibody fragments. It combines a rigid, high-flow agarose matrix with the immunoglobulin-binding protein L ligand. Capto L is therefore suitable for capture of a wide range of antibody fragments such as Fabs, single-chain variable fragments (scFv), and domain antibodies (dAbs, in addition to binding all classes of Ig (IgG, IgM, IgA, IgE and IgD).

Capto Core

Capto Core 700 is a multimodal chromatography medium that is designed for flowthrough purification of large proteins or viruses in vaccine processes. The multimodal property of the ligand in the core ensures strong binding with most impurities over a wide range of pH and salt concentration.

Benefits:

• Enabling significantly higher sample load
• Enabling higher flow rates
• Ensuring straightforward optimization and scale-up
   

AxiChrom™

The AxiChrom™ column platform is a revolutionary concept in column chromatography that simplifies column handling at all scales from process development to full-scale production. AxiChrom columns introduce three key features – Intelligent Packing, Intuitive handling, and Predictable scale-up – that together make process chromatography easier, safer, and more efficient.