Application Note | January 27, 2014

Parallel Integrity Testing Of Small Venting Filters

Source: Sartorius Stedim Biotech

Sterilizing grade venting filters are used to avoid the potential risk of air-borne germs contaminating containers like fermentors or cell-culture vessels. Sterilizing grade filtration can only be guaranteed when the filters used are tested for integrity. Therefore, such filters are routinely tested by the bubble point or similar tests. Depending on the program settings and the actual bubble point (BP), it can easily take 10–20 min to perform one such test. When a large number of filters are used and tested every day, it makes sense to think about how to make the test procedure more efficient without increasing the risk of overlooking defective filters.

This article describes a method by which Midisart venting filters can be tested efficiently by means of parallel testing. This parallel testing method drastically reduces the time required for testing, in turn yielding a clear economic benefit for users without compromising safety.

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