Application Note

Novel Method For The Expansion Of Mesenchymal Stem Cells

Source: Eppendorf, Inc

By Khandaker Siddiquee and Ma Sha

Stem cells are undifferentiated cells which have the capability of self-renewal and the potential to divide for a long period of time. They have the ability to differentiate into various specialized cells when appropriate growth factors and conditions are provided. Stem cells can be broadly classified as: embryonic, adult, and induced pluripotent stem cells (iPS). Adult stem cells can be further characterized by their tissue of origin, such as: hematopoietic, mammary, intestinal, mesenchymal, endothelial, neural, and hair follicle stem cells. Most of the studies performed on adult stem cells utilize either hematopoietic or adipose-derived mesenchymal stem cells.

Like other adult stem cells, adipose-derived mesenchymal stem cells (AdMSCs) express all of the common stem cell markers and can be differentiated into various types of APPLICATION NOTE No. AA259 I September 2013 specialized cells under appropriate growth conditions. AdMSCs have advantages over other mesenchymal stem cells (MSCs), since they can be isolated in large quantities from fat tissue and are resistant to apoptosis.

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