Navigating In The Single-Use Space: How To Find The Right Cell Culture BioreactorSource: GE Healthcare Life Sciences
The bioreactor is the cornerstone on which cell culture for biopharmaceutical production is based. The bioreactor should provide an efficient means to expand the cell culture and to repeatedly deliver a product with the desired quality attributes. Choosing the right bioreactor is vital, but how do you know which bioreactor is the most suitable for your applications?
From the early-day use of glass flasks in research and stainless steel vessels in manufacturing, the bioreactor has come a long way. A fundamental change in bioreactor technology is the shift to disposables. Although the use of stainless steel vessels still prevail at the very large manufacturing scales, single-use options are increasingly common in culture scales up to 2000 L. The benefits with disposables are now widely acknowledged for both upstream and downstream applications. Single-use equipment offers increased flexibility with quicker set-up and changeover between runs, and reduces the need for costly and time-consuming cleaning and cleaning validation operations.