Liquid-Filled Capsules

Patheon is one of the few companies capable and approved to develop and manufacture pharmaceuticals in both hard shell capsules and softgels; and no other company has deeper experience and resources.

The wide range of complex molecules of today's discoveries call for formulation solutions that improve solubility and bioavailability, especially for BCS Class II and Class IV products. Liquid filled capsules, both hard shell and softgel, are ideal for improving the delivery of the active pharmaceutical ingredient (API) to the body.

Patheon has the expertise and technology to take you from molecule to market:

• Both hard shell capsules and softgels
• Capsule design and composition
• Formulation development
• Mixing, encapsulation and banding
• Disposable equipment to accelerate your project
• Clinical supplies manufacturing
• Registration, scale-up, and validation batches
• Commercial production

With Patheon you benefit from knowledge built over thousands of different projects, formulations and molecules. No matter what challenges your drug substance presents, chances are we already have the experience and technology in place to keep your project moving forward quickly and seamlessly from early development all the way through commercial manufacturing.

Take full advantage of the benefits of liquid-filled hard-shell capsules

• Both gelatin and non-animal capsules
• Liquid-filled and biphasic liquid-filled capsules to improve solubility and bioavailability
• Coated beads in a liquid vehicle for fixed-dose combinations or to combine an immediate-release with a controlled-release drug
• Handles molten fills up to 75°C
• Superior uniformity and accuracy of dose for highly potent compounds
• Better containment for potent compounds
• Excellent protection for oxygen-sensitive APIs

Banding for tamper evidence, product identification, and improved sealing.