09.26.12 -- Improved Resolution Of Closely Related Peptides And Impurities

Phenyl Membrane Adsorber For Bioprocessing
By Sartorius Stedim Biotech
Hydrophobic phenyl membrane adsorbers with a macroporous structure have been developed. The chromatographic membranes are rolled up to cylindrical devices and incorporated into capsules with a bed height of 8 mm. The capsules are of the same design and housing materials as Sartobind capsules used in downstream processes for the removal of charged contaminants or for purification of large biomolecules or viruses. Read more.

A Novel Affinity Adsorbent For The Capture And Removal Of Endotoxin
By Bastiaan Lobbezoo, Jennifer Walden, Paul Beckett, Jason Shipp and Sharon Williams, ProMetic BioSciences Ltd.
Escherichia coli is a Gram-negative bacteria that is a popular host organism for the expression of recombinant protein biotherapeutics. Lysis of the outer membrane of Gram-negative bacteria, a requirement to release internalized target biomolecules, also releases substantial quantities of lipopolysaccharides (LPS — also known as endotoxin) into the process solution. Read more.

Viral Clearance Using Ion-Exchange Membrane Adsorber Capsules
By Pall Life Sciences
Viral contamination of cell banks is a potential risk in recombinant proteins produced by cell lines from animal or human origin. Licensed products must therefore be subjected to a process specific virus clearance strategy. Read more.