Peptide therapeutics have been recognized as delivering the best of both worlds in terms of small molecule synthesis efficiency and biologics efficacy and reduced toxicity. However, challenges in mass production and low oral availability have historically made them less than ideal drug candidates. Recent advances in peptide synthesis technologies now enable manufacturing of complex peptides on a very large scale. Read more.
Phenyl Membrane Adsorber For Bioprocessing
By Sartorius Stedim Biotech
Hydrophobic phenyl membrane adsorbers with a macroporous structure have been developed. The chromatographic membranes are rolled up to cylindrical devices and incorporated into capsules with a bed height of 8 mm. The capsules are of the same design and housing materials as Sartobind capsules used in downstream processes for the removal of charged contaminants or for purification of large biomolecules or viruses. Read more.
A Novel Affinity Adsorbent For The Capture And Removal Of Endotoxin
By Bastiaan Lobbezoo, Jennifer Walden, Paul Beckett, Jason Shipp and Sharon Williams, ProMetic BioSciences Ltd.
Escherichia coli is a Gram-negative bacteria that is a popular host organism for the expression of recombinant protein biotherapeutics. Lysis of the outer membrane of Gram-negative bacteria, a requirement to release internalized target biomolecules, also releases substantial quantities of lipopolysaccharides (LPS — also known as endotoxin) into the process solution. Read more.