HyperCel™ STAR AX

HyperCel STAR AX sorbent is an industry-scalable anion exchange chromatography sorbent designed for high productivity protein capture at moderate or higher salt conductivity (2 to 15 mS/cm), typical of undiluted biological feedstocks (i.e., mammalian cell culture supernatants, E. coli feedstock, plasma, others…).

HyperCel STAR AX sorbent is an industry-scalable anion exchange chromatography sorbent designed for high productivity protein capture at moderate or higher salt conductivity (2 to 15 mS/cm), typical of undiluted biological feedstocks (i.e., mammalian cell culture supernatants, E. coli feedstock, plasma, others…).

Applications include direct capture of recombinant proteins, monoclonal and polyclonal antibodies, plasma derivatives or other biopharmaceuticals.

Due to its ability to capture directly proteins from undiluted feedstreams, HyperCel STAR AX sorbent can also be used for early contaminant removal (i.e., CHO Host Cell Proteins), before target purification, i.e., before MAb capture by a Protein A affinity step.

HyperCel STAR AX sorbent is manufactured at large scale and meets the needs of industrial users and regulatory authorities. A Regulatory Support File (RSF) is available to assist users in the development of validation procedures. This sorbent offers:

• High dynamic binding capacity (DBC) at short residence time (2 minutes or lower)
• Direct capture of protein from undiluted feedstock at moderate or high conductivity
• Excellent flow rate properties for fast feedstock processing
• Distinctive selectivity, consistent in a broad conductivity range (2 – 15 mS/cm)
• Enhanced process economics