How To Improve Isolation And Purification Of Natural Product ExtractsSource: Grace
Natural products continue to play a significant role in the discovery of bioactive agents and development of new therapies and treatments. Crude natural product extracts typically contain lead compounds requiring multiple steps to isolate and purify. Conventional flash purification techniques used for isolating such compounds either fail to detect compounds that are non-chromophoric, or lack the necessary sensitivity required for detection of low level components.
The natural products field continues to explore small molecule research and discovery of new chemical entities. Research laboratories modify active natural product skeletons to identify novel agents that benefit various physiological processes and link mother nature to combinatorial synthetic techniques.
To discover chemical agents with greater diversity for more efficacious natural treatments, scientists need to investigate all possible routes to novel agents that await discovery from terrestrial to marine environments. Synthesis of natural product-like libraries is ongoing, as they continue to provide leads for new agents and bioactive ingredients for the medicinal and cosmetic industries. The exploration of nature can ultimately provide leads and effective scaffolds for phytotherapies and organic treatments.