Greater Productivity In Insulin PurificationSource: Grace
Insulin is a peptide hormone, produced by beta cells of the pancreas, and regulates carbohydrate and fat metabolism in the body. Insulin causes cells in the liver, skeletal muscles, and fat tissue to absorb glucose from the blood. Biosynthetic insulin is manufactured for widespread clinical use using recombinant DNA technology in order to treat diabetes.
It is estimated that growth of insulin production will continue at a brisk 9% year over year as the incidence of diabetes continues to grow and new technologies allow greater transport and access to insulin globally. Currently, there are nearly 6,000 new insulin drugs in clinical trial studies.
Biopharmaceuticals, are much more likely to require purification chromatography due to the complexity of sample matrixes. One of the earliest classes of biopharmaceuticals to use chromatography in its production was human insulin, specifically reversed phase chromatography. This powerful purification technique continues to be the method of choice due to the degree of resolution and purity it provides.