Introducing Nuvia HR-S Chromatography Media
Nuvia HR-S media is a new strong cation exchanger optimized for particle size and chemistry that offers exceptional resolution and high recovery. It demonstrates fast mass transfer kinetics, excellent flow characteristics, and robust chemical stability against common caustic cleaning protocols. Its scalability provides confidence that results obtained on the bench will be reproducible for large-scale downstream manufacturing. Nuvia HR-S media is the preferred solution for intermediate and final polish applications. Learn more.
By Kathryn Martin Remington, Ph.D., Principal Scientist for Clearance Services, BioReliance
A common concern for manufacturers of biopharmaceutical products is whether their process achieves sufficient viral clearance. There is no fixed level of viral reduction that all manufacturing processes for biopharmaceutical products must achieve. Each biopharmaceutical product uses unique source materials and a unique manufacturing process, and so each product has its own unique risk for potential viral transmission. Therefore, the level of viral reduction required to achieve an acceptable viral safety risk is specific to each product.
By Lori Clapper A Q&A With Brent Todd, ATMI Life Sciences.
Q: Can you compare pressure decay and helium integrity testing?
A: Most bags today are tested by pressure decay, which is the industry standard, and it works fine — but there are some limitations to this technology. As customers begin using single-use assemblies further and further downstream, they have a need to increase their assurance of integrity and sterility in their single-use manifolds, bags, etc. That is why ATMI developed the innovative Helium Integrity Tester (HITTM) — to do just that.
By Rakesh Bose, Scott Anderson, Kathy Lawrence, and Melissa Wilcox, Grace
Carbohydrates are commonly found as constituents in plants, animals, and microorganisms. Carbohydrate units have considerable applications in medicine when bound to lipids, peptides, proteins, or even nucleic acids. Total synthesis of bioactive natural products, amino glycoside antibiotics, glycodrugs, and glycoconjugate vaccines from carbohydrates have been of considerable interest in the medicinal field for cures. Due to their therapeutic effects, conjugation of carbohydrates and their presence in antibiotics can be effectively used to find cures for the treatment of various diseases. Besides their clinical importance in glycomics, synthesizing and purifying such molecules has been a challenge to synthetic chemists.
By Tom Burton, President Liquidity Services’ Capital Asset Group
Whether a small enterprise or large institution, many organizations have and will be faced with the challenge of closing a lab. No matter what the size or scope of the closure, the person tasked with closing the facility faces a daunting assignment: millions of dollars in real estate, laboratory equipment, and research devices will need to be redeployed, sold, or disposed of.
By Paul Held Ph.D. and Peter Banks, Ph.D., BioTek Instruments, Inc.
The imaging and analysis of fluorescently stained cells has traditionally been accomplished using manual microscopic methods with low numbers of samples, while the analysis of higher sample numbers requires the use of very expensive dedicated microscopes.
By Kathrin Schmale, Strategic Marketing Manager, DASGIP, and Karl Rix, CEO, DASGIP BioTools, LLC
Advanced benchtop bioreactors can harmonize unit operations between development and production, while supporting the aims of quality by design.