12.17.12 -- Fragile X Protein Linked To Nearly 100 Genes Involved In Autism

Improving DNA Removal From Bioprocess Purification Processes

Many new biological drug products using recombinant DNA technology, such as monoclonal antibodies, are produced in cell culture. The host cell produces the therapeutic proteins that are often secreted outside the cell into the surrounding culture medium. Impurities can result from the host cells or cell substrates, such as host cell protein and host cell DNA. This application brief addresses removal of DNA using cellulosic depth filters. Learn more.

Featured Articles

Homogenization Of Vaccines
By Robert Cupka, GEA Niro Soavi
Since the late nineteenth century, public health officials have recommended and enforced vaccines for a small number of highly infectious and communicable diseases. Vaccines work with the immune system's ability to recognize and destroy foreign proteins (antigens) that it determines are "nonself." Today, however, there are more than 200 new vaccines in the research pipeline, including one for HIV.

Decontamination Of Laboratory Animal Research Rooms Using Vaporized Hydrogen Peroxide
By G. McDonnell, Steris
Walter Reed Army Institute for Research is a U.S. government laboratory facility located in the Washington D.C. area. The institute houses an animal research facility consisting of more than 15 animal rooms, designed for several different types of laboratory research animals, a BL2 lab, and a BL3 lab. The focus of this case study is cycle development and decontamination testing of two animal rooms having volumes of 1750 ft³ (50 m³) and 1875 ft³ (53 m³) using a VHP 1000 Biodecontamination System.

IFPAC®-2013: The Premier International Event On QbD And PAT

January 22 to 25, 2013 • Baltimore Marriott Waterfront

IFPAC is the essential meeting place for the latest developments in Process Analytical Technology (PAT) and Quality by Design (QbD). IFPAC provides a dynamic platform for proactive discussions between industry, government, research institutions, and manufacturers/suppliers in the pharmaceutical/biotechnology and related industries. IFPAC-2013 will provide an opportunity to interact with industries that have been using PAT for nearly 60 years! Email: info@ifpacnet.org; Phone: (847) 543-6800; www.ifpacpat.org

Spotlight On Laboratory Equipment And Services

Getinge 633LS Steam Sterilizers
The Getinge 633LS Vacuum/Gravity Steam Sterilizer delivers superior performance and productivity in a midsize unit. Getinge designed the 633LS Vacuum/Gravity Steam Sterilizer to increase the standard load capacity, compared to other similar size units, which will increase the throughput in the same amount of space.

EMC Documentum For Life Sciences eTMF Solution
With the growing trend of life sciences companies utilizing contract research organizations (CROs) for the vast majority of clinical trials, now, more than ever, documentation has become more complex, and it is essential that companies find a documentation solution which will reduce risk and meet compliance requirements.

Simplifying And Accelerating The R&D Process With OpenLAB Electronic Laboratory Notebook
e2v Biosensors, a wholly owned subsidiary of e2v technologies, is developing a range of new products for drug discovery and medical diagnostics. One of these products is Visulife, a benchtop analyzer with integrated biochips and a reader that enables the rapid and reliable analyses of proteins.

Biomanufacturing Debottlenecking And Process Optimization
Optimizing biomanufacturing is particularly challenging because of the variability and complexity associated with the sharing of finite and interdependent resources.

Inflammation And The New Drug Development Paradigm
Opportunities abound for new treatments for inflammatory diseases, which afflict millions of people. Upward spiraling development costs, however, impede progress and delay relief for patients suffering from such debilitating diseases.

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