Newsletter | June 4, 2014

06.04.14 -- Essentialis' DCCR For Prader-Willi Syndrome Granted Orphan Drug Status

Bioresearch Online Newsletter
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Cargo theft is nothing new. Since goods have been shipped there have been those ready to take advantage. The theft of pharmaceutical supplies affects the industry in ways beyond the bottom line with patient safety threatened by counterfeit and badly handled supplies. In this joint presentation World Courier's Sue Lee and Jason Breakwell Director of TAPA (Transported Asset Protection Association) will discuss the problem, and how it affects the supply chain and ultimately the patient. Learn more.

Featured Content

Application Note: Kinase Assay Using A 3D Tumoroid- Based Cell Model
By Brad Larson, Peter Banks, Nicolas Pierre, and Grant Cameron, BioTek Instruments, Inc.
Three-dimensional (3D) cell culture is poised to meet the need for a more in vivo-like cellular model with which to test large and small molecules. This is accomplished by providing a method that allows for the reorganization of cells into a format that re-establishes the necessary cellular architecture and communication networks seen in normal tissue. Recently a methodology has been put forth that incorporates a simplified procedure for the creation of a cell and collagen hydrogel mix. The inclusion of appropriate liquid handling instrumentation can further simplify the process and ensure the generation of accurate, robust results.


Application Note: Using Flash Chromatography With ELSD And UV Detection For Rapid Purification Of Peptides
By Jeff Horsman, Kathryn Lawrence, Bopanna N.K., Chitra Sundararajan, Melissa Wilcox, Grace, Janos Varga, Fabio Simi, Mitzi Pezes, California Peptide Research
Flash chromatography is a fast and cost-efficient approach to purify synthetic peptides and other small molecules. Using flash chromatography can quickly increase overall purity of peptides prior to the next amino acid addition or final polishing on preparative HPLC.


Application Note: Purification Of An N-Terminal Histidine-Tagged Protein Using ÄKTA Start
By GE Healthcare Life Sciences
ÄKTA start eliminates the hassles of manual protein purification handling, such as loading large sample volumes and continually monitoring UV readings, and can give you consistency of yield and purity. Madhu demonstrates how ÄKTA start aided him in purifying a recombinant N-terminal histidine-tagged protein.


White Paper: Accelerate Growth Medium Optimization
By Irvine Scientific
Formulation development and optimization can be successfully achieved through a variety of approaches. The diversity of the media panel in Irvine Scientific’s CHO Media Development Kit allows you to create a formulation development strategy that fits with your project timeline, resources, and goals. All the media provided in this kit have been fully engineered to be made at full GMP scale. With the media being GMP ready, the kit can help shorten the development time to an EMS or GMP product.

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Upcoming Training

 


CRA Oversight — A Risk-Based Approach
Date: Tuesday, June 10, 2014 • Time: 1pm to 2:30pm EST

The Future Of Biosimilars: Addressing Regulatory Challenges
Date: Thursday, June 19, 2014 • Time: 1pm to 2:30pm EST

Featured Downloads

Sartoguard GF Membrane Prefiltration Filter Elements
Sartoguard GF filter elements consist of glass fiber layers and Polyethersulfone membranes. They combine the defined retention performance for particles and microorganisms of membrane filters with the high total throughput capacity in the depth of the fibrous material.

AseptiQuik STC Connectors Datasheet
AseptiQuik STC Connectors integrate the AseptiQuik sterile connector and the Steam-Thru II SIP connector, giving manufacturers even greater flexibility for hybrid stainless steel and single-use processing.

HyQ BioProcess Containers For Sterile Fluid Handling
Thermo Scientific HyQ BioProcess Container Systems are large-volume liquid handling systems for cell culture and bioprocessing.

Sterilizing Filtration Of Enriched And Pure Gaseous Oxygen Employed In Cell Culture Applications
Modern bioreactor aeration concepts increasingly use oxygen-enriched air or pure oxygen gas to improve cell culture productivity. As with air, these alternate oxygen-source gas feeds must be filter-sterilized to prevent spoilage of bioreactors by contaminant organisms coming from the incoming and outgoing gas streams. Membrane filters are used to sterilize these gases, and they must also be integrity testable to assure process security and meet GMP requirements.
Browse the download library

Upcoming Webinar

Transform And Redefine Biopharmaceutical Purification With Innovative Process Solutions
In this webinar you will learn about the Emphaze AEX Hybrid Purifier — a multimechanism clarification device that embodies the philosophy of innovation necessary to transform and redefine the mAb purification process.

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Air Cargo Integrity: Real-Time Tracking
Air Cargo Integrity: Real-Time Tracking

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Compact, Microvolume Protein Analysis And Characterization
Compact, Microvolume Protein Analysis And Characterization

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Custom-Designed, Molded Silicone Manifolds
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DNA And siRNA Transfection Reagent
DNA And siRNA Transfection Reagent

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