E-Beam Pharmaceutical BiodecontaminationSource: Getinge USA, Inc.
When materials are required during continuous processing within the isolator there are limited ways of maintaining the sterile environment.
When materials are required during continuous processing within the isolator there are limited ways of maintaining the sterile environment. Passing materials in through lockchambers with rapid independent bio-decontamination is one way, but this is batch-based and may be a bottleneck to production.
Getinge's STERSTAR e-beam system, pictured above, and described in the Sterilization Equipment section is purpose designed for rapid, continuous surface bio-decontamination of syringe tubs, and is a good example of the way e-beam can be used for this application.
Similarly, continuous production means that materials produced must be passed out of the isolator. While isolators provide a good degree of Sterility Assurance (compared with production in a clean room), Terminal Sterilization should be used whenever possible. The Getinge STERBOX system provides continuous e-beam sterilization of filled liquid product as it exits the isolated production line. Read more in the Sterilization Equipment section.