DASware Design: DoE With Parallel Bioreactor Systems DatasheetSource: DASGIP Information and Process Technology GmbH an Eppendorf company
State-of-the-art process development follows Quality by Design (QbD) guidelines. Risk analysis is used to reduce the number of factors considered to have an impact on the product quality. Design of Experiments (DoE) and Multivariate Analysis (MVA) are structured approaches for development and optimization of processes. Compared to the One-factor-at-a-time method they reduce the number of process runs necessary to determine a proper design space for the manufacturing process. Therefore, they are cost-effective and play a prominent role in process development and screening procedures.
As part of the DASware bioprocessing software suite, DASware design was developed to apply DoE concepts to bioprocessing. It comes with a full factorial DoE Builder and also allows for automated import of DoE designs from most powerful 3rd party DoE statistical tools like JMP and others. DASware design automatically compiles DoE information from these tools into recipes and feedback response information into DoE and multivariate analysis and reporting tools.
DASGIP Benchtop Bioreactor Systems serve as an ideal platform to implement DoE on bioreactors in parallel. Following DASGIP’s Point-Click-Grow concept, parallel recipes incorporating DoE factor variation (e.g. pH, dissolved oxygen, temperature set-points or feed rates) can be carried out on a set of bioreactors with a few easy mouse clicks.