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Closed Systems For Small-Scale Single-Use Applications
A Q&A With Brent Bushnell, Bioprocess Applications Specialist, Colder Products Company |
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Closed single-use systems reduce the risk of two critical forms of contamination: biological contamination and cross-contamination. Biological contamination includes competitive organisms such as bacteria, fungi, and yeasts that are inadvertently introduced into cell culture processes. These organisms utilize culture nutrients, produce unwanted proteins, and limit growth or destroy the intended cell culture. Most biological contaminations result in rapid growth and observable culture changes that indicate a culture must be discarded.
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Featured Articles |
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Scaling-Up Adherent Stem Cell Cultures: Importance Of Physioenvironmental Control By Multiplate Bioreactors
By F. Collignon, J. Goffinet, J.C. Drugmand, et al, ATMI LifeSciences
Single-use bioreactors minimize manual handling, realizing economies of scale and delivering the benefits of a closed system for stem-cell-based products. Nevertheless, process development and scale-up may be challenging, as small variations in physicochemical parameters, such as surface characteristics, pH, and dissolved oxygen, can heavily impact stem cell growth and behavior. Preserving the cell culture environment and mitigating risk during process scale-up is critical. Read more.
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Benefits Of Single-Use Technology In Commercial Filling Operations
By Eric Isberg, Product Manager, Bosch Packaging Technology
Single use technology continues to gain popularity in pharmaceutical and biopharmaceutical operations. One area where single use technology would be very beneficial is in product final filling. The following paper highlights the various benefits of disposables for product filling operations. Read more.
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Continuous Quality Verification As A Control Strategy For Biocontainers
By Max Blomberg and Christian Julien, Meissner Filtration Products, Inc.
Integrity testing of single-use systems, such as biocontainer and tubing assemblies used in the processing of biopharmaceutical solutions, continues to emerge as one of the most sought after means to ensure "integrity" at the point of use. Read more.
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