Discover ATMI LifeSciences' latest innovation: the Integrity® PadReactor™ Mini bioreactor. Based on an innovative cube-shaped bag, it incorporates an efficient mixing paddle and a strong sparging device for superior mix¬ing capabilities, as well as improved gas transfer. With a maximum working volume of 13L, the PadReactor Mini works with both suspension cells and adherent cells on microcarriers making it a nice tool for process development and small production of proteins, viruses and stem cells. Learn more.
By Dr. Kirk Beebe, Director of Application Science, Metabolon, Inc.
Biologics are an integral part of the landscape of current therapies as pipelines continue to fill with them. Due to their importance, and this ever-expanding pipeline, the demands continue to escalate due to cost pressure, competition, regulatory requirements, disposable systems, and biosimilars. To date, these demands arguably have primarily been met with empirical understanding. However, there is a critical need for new approaches, tools, and technologies to deliver deeper understanding beyond the empirical realm.
By Brad Larson and Peter Banks, BioTek Instruments, Inc.; Nicolas Pierre, CisBio US Inc.; and Stephanie Georgiou, Enzo Life Sciences
Epidermal growth factor receptor (EGFR) is expressed in up to 70 percent of epithelial ovarian cancers (EOCs). High levels of IL-6 have also been found in the ascites of EOC patients. It has been shown that ligand stimulated EGFR activated NFkB dependent transcription and induced secretion of the pro-inflammatory IL-6 cytokine.
By Scott Anderson, Kathy Lawrence, Dennis McCreary, and Melissa Wilcox
By using the RevealX™ detection technology of the Reveleris® system, which independently triggers fraction collection from multiple detectors including UV and ELSD, this work will demonstrate that these bottlenecks can be reduced or eliminated without reducing the recovery of compounds of interest.
By Trisha Gladd, Editor, Pharmaceutical Online and Bioresearch Online
When it comes to equipment manufacturing in the pharmaceutical industry, it is imperative that a product functions exactly as it was intended. Any misstep caused by faulty equipment could have catastrophic results for the company that produces a drug, but more importantly, for the patient who uses it. The serious consequences that can result from a lack of accurate equipment design and the associated manufacturing processes are why Donald Dobert, president and COO of ATL Pharmaceutical/Medical, created his company’s New Product Development (NPD) Planning Process.
By Dr. Frank Westad, Chief Scientific Officer, CAMO Software
Multivariate statistical process monitoring (MSPM) has been established as a valuable tool for ensuring reliable product quality in the process industry. However, many organizations today are still not fully utilizing its potential to make significant improvements in their production environment.
By Mark Mohr, CSafe Global
Ensuring that your shipment stays at the required constant temperature throughout the delivery chain requires the right packaging and handling, as the cost of losing an entire shipment of product to spoilage and the associated damage to your business could be disastrous.