Newsletter | March 20, 2013

03.20.13 -- Minimizing Purification Bottlenecks Using A Multidetector Approach To Flash Chromatography

Bioresearch Online
Minimizing Purification Bottlenecks Using
A Multidetector Approach To Flash Chromatography

By Scott Anderson, Kathy Lawrence, Dennis McCreary, and Melissa Wilcox, Grace
By using the RevealX™ detection technology of the Reveleris® system, which independently triggers fraction collection from multiple detectors including UV and ELSD, this work will demonstrate that these bottlenecks can be reduced or eliminated without reducing the recovery of compounds of interest.
Read more.
Featured Articles

Ready-To-Use Fluid Management Solutions For Chromatography Systems
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A selection of fluid management components from the GE Healthcare ReadyToProcess platform of disposable and single-use equipment was used to arrange buffer and sample management solutions for four typical, large-scale chromatography setups. Read more.

Skid-Mounted Liquid Chromatography Systems
By Integrated Process Engineers & Constructors Inc. (IPEC)
IPEC provided three skid-mounted liquid chromatography systems to Cook Pharmica, located in Bloomington, Indiana. The systems consisted of piping, valves, pumps, filters, bubble traps, and instrumentation, and are suitable for operation under cGMP guidelines. The systems are capable of in-place cleaning and sanitization. Read more.

A Purification Strategy For Clinical-Grade Monoclonal Antibodies Using Hydrophobic Cation Exchange Chromatography
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Monoclonal antibodies are currently the most important class of therapeutic proteins. This application demonstrates that a three-step, nonaffinity workflow can effectively deliver highly purified monoclonal antibodies with minimal feed conditioning. Read more.

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